Focused VHEE (very high energy electron) beams and dose delivery for radiotherapy applications
Mackay, R. I.
van Herk, M.
Jones, J. K.
Jones, R. M.; email: Roger.Jones@manchester.ac.uk
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AbstractAbstract: This paper presents the first demonstration of deeply penetrating dose delivery using focused very high energy electron (VHEE) beams using quadrupole magnets in Monte Carlo simulations. We show that the focal point is readily modified by linearly changing the quadrupole magnet strength only. We also present a weighted sum of focused electron beams to form a spread-out electron peak (SOEP) over a target region. This has a significantly reduced entrance dose compared to a proton-based spread-out Bragg peak (SOBP). Very high energy electron (VHEE) beams are an exciting prospect in external beam radiotherapy. VHEEs are less sensitive to inhomogeneities than proton and photon beams, have a deep dose reach and could potentially be used to deliver FLASH radiotherapy. The dose distributions of unfocused VHEE produce high entrance and exit doses compared to other radiotherapy modalities unless focusing is employed, and in this case the entrance dose is considerably improved over existing radiations. We have investigated both symmetric and asymmetric focusing as well as focusing with a range of beam energies.
CitationScientific Reports, volume 11, issue 1, page 14013
PublisherNature Publishing Group UK
DescriptionFrom Springer Nature via Jisc Publications Router
History: received 2021-04-21, accepted 2021-06-10, registration 2021-06-23, pub-electronic 2021-07-07, online 2021-07-07, collection 2021-12
Publication status: Published
Funder: Engineering and Physical Sciences Research Council; doi: http://dx.doi.org/10.13039/501100000266; Grant(s): EPZ EPSRC PHYSICS DTP 2018-2023
Funder: Science and Technology Facilities Council; doi: http://dx.doi.org/10.13039/501100000271; Grant(s): IAA 2015