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dc.contributor.authorO’Mara, Tracy A.
dc.contributor.authorCrosbie, Emma J.; orcid: 0000-0003-0284-8630; email: emma.crosbie@manchester.ac.uk
dc.date.accessioned2021-07-06T15:14:46Z
dc.date.available2021-07-06T15:14:46Z
dc.date.issued2020-07-06
dc.date.submitted2020-04-08
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/625155/41416_2020_Article_959.pdf?sequence=2
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/625155/41416_2020_Article_959_nlm.xml?sequence=3
dc.identifier.citationBritish Journal of Cancer, volume 123, issue 7, page 1045-1046
dc.identifier.urihttp://hdl.handle.net/10034/625155
dc.descriptionFrom Springer Nature via Jisc Publications Router
dc.descriptionHistory: received 2020-04-08, rev-recd 2020-06-03, accepted 2020-06-10, registration 2020-06-12, pub-electronic 2020-07-06, online 2020-07-06, pub-print 2020-09-29
dc.descriptionPublication status: Published
dc.description.abstractSummary: Recent large-scale genetic studies, particularly genome-wide association studies (GWAS), have emphasised the importance of common genetic variation in endometrial cancer susceptibility. Although each of these variants only confer modest effects on endometrial cancer risk, together they are likely to explain a substantial amount of the familial relative risk of the disease. Therefore, methods to combine genetic risk variants, such as polygenic risk scores (PRS) have gained traction as an attractive method for individualised risk prediction and management. Here, we discuss the benefits of a PRS for endometrial cancer and considerations required for clinical implementation.
dc.languageen
dc.publisherNature Publishing Group UK
dc.rightsLicence for this article: http://creativecommons.org/licenses/by/4.0/
dc.sourcepissn: 0007-0920
dc.sourceeissn: 1532-1827
dc.subjectComment
dc.subject/692/499
dc.subject/692/4028/67/1517/1931
dc.subjectcomment
dc.titlePolygenic risk score opportunities for early detection and prevention strategies in endometrial cancer
dc.typeother
dc.date.updated2021-07-06T15:14:45Z
dc.date.accepted2020-06-10


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