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dc.contributor.authorValpione, Sara
dc.contributor.authorMundra, Piyushkumar A.
dc.contributor.authorGalvani, Elena
dc.contributor.authorCampana, Luca G.; orcid: 0000-0002-8466-8459
dc.contributor.authorLorigan, Paul; orcid: 0000-0002-8875-2164
dc.contributor.authorDe Rosa, Francesco; orcid: 0000-0003-0511-1298
dc.contributor.authorGupta, Avinash
dc.contributor.authorWeightman, John
dc.contributor.authorMills, Sarah
dc.contributor.authorDhomen, Nathalie
dc.contributor.authorMarais, Richard; orcid: 0000-0001-7484-4183; email: richard.marais@cruk.manchester.ac.uk
dc.date.accessioned2021-07-02T15:21:42Z
dc.date.available2021-07-02T15:21:42Z
dc.date.issued2021-07-02
dc.date.submitted2020-07-30
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/625119/41467_2021_24343_MOESM2_ESM.pdf?sequence=2
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/625119/41467_2021_24343_MOESM1_ESM.pdf?sequence=3
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/625119/41467_2021_Article_24343_nlm.xml?sequence=4
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/625119/additional-files.zip?sequence=5
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/625119/41467_2021_Article_24343.pdf?sequence=6
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/625119/41467_2021_24343_MOESM3_ESM.pdf?sequence=7
dc.identifier.citationNature Communications, volume 12, issue 1, page 4098
dc.identifier.urihttp://hdl.handle.net/10034/625119
dc.descriptionFrom Springer Nature via Jisc Publications Router
dc.descriptionHistory: received 2020-07-30, accepted 2021-06-09, registration 2021-06-16, pub-electronic 2021-07-02, online 2021-07-02, collection 2021-12
dc.descriptionPublication status: Published
dc.descriptionFunder: Harry J. Lloyd Charitable Trust; doi: https://doi.org/10.13039/100005976; Grant(s): Career Development Award
dc.descriptionFunder: Cancer Research UK (CRUK); doi: https://doi.org/10.13039/501100000289; Grant(s): A27412, A22902
dc.descriptionFunder: Wellcome Trust (Wellcome); doi: https://doi.org/10.13039/100004440; Grant(s): 100282/Z/12/Z
dc.description.abstractAbstract: Tumor infiltration by T cells is paramount for effective anti-cancer immune responses. We hypothesized that the T cell receptor (TCR) repertoire of tumor infiltrating T lymphocytes could therefore be indicative of the functional state of these cells and determine disease course at different stages in cancer progression. Here we show that the diversity of the TCR of tumor infiltrating T cell at baseline is prognostic in various cancers, whereas the TCR clonality of T cell infiltrating metastatic melanoma pre-treatment is predictive for activity and efficacy of PD1 blockade immunotherapy.
dc.languageen
dc.publisherNature Publishing Group UK
dc.rightsLicence for this article: http://creativecommons.org/licenses/by/4.0/
dc.sourceeissn: 2041-1723
dc.subjectArticle
dc.subject/631/67/1059/2325
dc.subject/631/114/2415
dc.subject/692/53/2423
dc.subject/692/4028/67/580
dc.subject/38/91
dc.subject/38/23
dc.subjectarticle
dc.titleThe T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival
dc.typearticle
dc.date.updated2021-07-02T15:21:42Z
dc.date.accepted2021-06-09


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