The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival
Mundra, Piyushkumar A.
Campana, Luca G.; orcid: 0000-0002-8466-8459
Lorigan, Paul; orcid: 0000-0002-8875-2164
De Rosa, Francesco; orcid: 0000-0003-0511-1298
Marais, Richard; orcid: 0000-0001-7484-4183; email: firstname.lastname@example.org
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AbstractAbstract: Tumor infiltration by T cells is paramount for effective anti-cancer immune responses. We hypothesized that the T cell receptor (TCR) repertoire of tumor infiltrating T lymphocytes could therefore be indicative of the functional state of these cells and determine disease course at different stages in cancer progression. Here we show that the diversity of the TCR of tumor infiltrating T cell at baseline is prognostic in various cancers, whereas the TCR clonality of T cell infiltrating metastatic melanoma pre-treatment is predictive for activity and efficacy of PD1 blockade immunotherapy.
CitationNature Communications, volume 12, issue 1, page 4098
PublisherNature Publishing Group UK
DescriptionFrom Springer Nature via Jisc Publications Router
History: received 2020-07-30, accepted 2021-06-09, registration 2021-06-16, pub-electronic 2021-07-02, online 2021-07-02, collection 2021-12
Publication status: Published
Funder: Harry J. Lloyd Charitable Trust; doi: https://doi.org/10.13039/100005976; Grant(s): Career Development Award
Funder: Cancer Research UK (CRUK); doi: https://doi.org/10.13039/501100000289; Grant(s): A27412, A22902
Funder: Wellcome Trust (Wellcome); doi: https://doi.org/10.13039/100004440; Grant(s): 100282/Z/12/Z