The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival
Authors
Valpione, SaraMundra, Piyushkumar A.
Galvani, Elena
Campana, Luca G.; orcid: 0000-0002-8466-8459
Lorigan, Paul; orcid: 0000-0002-8875-2164
De Rosa, Francesco; orcid: 0000-0003-0511-1298
Gupta, Avinash
Weightman, John
Mills, Sarah
Dhomen, Nathalie
Marais, Richard; orcid: 0000-0001-7484-4183; email: richard.marais@cruk.manchester.ac.uk
Publication Date
2021-07-02Submitted date
2020-07-30
Metadata
Show full item recordAbstract
Abstract: Tumor infiltration by T cells is paramount for effective anti-cancer immune responses. We hypothesized that the T cell receptor (TCR) repertoire of tumor infiltrating T lymphocytes could therefore be indicative of the functional state of these cells and determine disease course at different stages in cancer progression. Here we show that the diversity of the TCR of tumor infiltrating T cell at baseline is prognostic in various cancers, whereas the TCR clonality of T cell infiltrating metastatic melanoma pre-treatment is predictive for activity and efficacy of PD1 blockade immunotherapy.Citation
Nature Communications, volume 12, issue 1, page 4098Publisher
Nature Publishing Group UKType
articleDescription
From Springer Nature via Jisc Publications RouterHistory: received 2020-07-30, accepted 2021-06-09, registration 2021-06-16, pub-electronic 2021-07-02, online 2021-07-02, collection 2021-12
Publication status: Published
Funder: Harry J. Lloyd Charitable Trust; doi: https://doi.org/10.13039/100005976; Grant(s): Career Development Award
Funder: Cancer Research UK (CRUK); doi: https://doi.org/10.13039/501100000289; Grant(s): A27412, A22902
Funder: Wellcome Trust (Wellcome); doi: https://doi.org/10.13039/100004440; Grant(s): 100282/Z/12/Z