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dc.contributor.authorThomas, Josephine M.; orcid: 0000-0002-1787-1748; email: josephine.thomas@manchester.ac.uk
dc.contributor.authorLouca, Irene; orcid: 0000-0001-6982-4209
dc.contributor.authorBolan, Faye; orcid: 0000-0003-4182-544X
dc.contributor.authorSava, Oana‐Roxana; orcid: 0000-0002-4800-9077
dc.contributor.authorAllan, Stuart M.; orcid: 0000-0001-9646-4456
dc.contributor.authorLawrence, Catherine B.; orcid: 0000-0002-2372-2968
dc.contributor.authorPinteaux, Emmanuel; orcid: 0000-0002-9986-4401
dc.date.accessioned2021-07-01T14:19:29Z
dc.date.available2021-07-01T14:19:29Z
dc.date.issued2021-07-01
dc.date.submitted2021-03-09
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/625105/adhm.202100455.xml?sequence=2
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/625105/adhm.202100455.pdf?sequence=3
dc.identifier.citationAdvanced Healthcare Materials, page 2100455
dc.identifier.urihttp://hdl.handle.net/10034/625105
dc.descriptionFrom Wiley via Jisc Publications Router
dc.descriptionHistory: received 2021-03-09, rev-recd 2021-06-15, pub-electronic 2021-07-01
dc.descriptionArticle version: VoR
dc.descriptionPublication status: Published
dc.descriptionFunder: Engineering and Physical Sciences Research Council; Id: http://dx.doi.org/10.13039/501100000266
dc.descriptionFunder: Medical Research Council; Id: http://dx.doi.org/10.13039/501100000265; Grant(s): EP/L014904/1
dc.description.abstractAbstract: Intracerebral hemorrhage (ICH) is a deadly and debilitating type of stroke, caused by the rupture of cerebral blood vessels. To date, there are no restorative interventions approved for use in ICH patients, highlighting a critical unmet need. ICH shares some pathological features with other acute brain injuries such as ischemic stroke (IS) and traumatic brain injury (TBI), including the loss of brain tissue, disruption of the blood–brain barrier, and activation of a potent inflammatory response. New biomaterials such as hydrogels have been recently investigated for their therapeutic benefit in both experimental IS and TBI, owing to their provision of architectural support for damaged brain tissue and ability to deliver cellular and molecular therapies. Conversely, research on the use of hydrogels for ICH therapy is still in its infancy, with very few published reports investigating their therapeutic potential. Here, the published use of hydrogels in experimental ICH is commented upon and how approaches reported in the IS and TBI fields may be applied to ICH research to inform the design of future therapies is described. Unique aspects of ICH that are distinct from IS and TBI that should be considered when translating biomaterial‐based therapies between disease models are also highlighted.
dc.languageen
dc.rightsLicence for VoR version of this article: http://creativecommons.org/licenses/by/4.0/
dc.sourceissn: 2192-2640
dc.sourceissn: 2192-2659
dc.subjectPerspective
dc.subjectPerspectives
dc.subjectacute brain injury
dc.subjecthydrogels
dc.subjectintracerebral hemorrhage
dc.subjectregenerative medicine
dc.subjectstroke
dc.titleRegenerative Potential of Hydrogels for Intracerebral Hemorrhage: Lessons from Ischemic Stroke and Traumatic Brain Injury Research
dc.typearticle
dc.date.updated2021-07-01T14:19:29Z


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