The Relationship between Body Mass Index and Mammographic Density during a Premenopausal Weight Loss Intervention Study
dc.contributor.author | Atakpa, Emma C.; email: e.c.atakpa@qmul.ac.uk | |
dc.contributor.author | Brentnall, Adam R.; email: a.brentnall@qmul.ac.uk | |
dc.contributor.author | Astley, Susan; email: Sue.astley@manchester.ac.uk | |
dc.contributor.author | Cuzick, Jack; email: j.cuzick@qmul.ac.uk | |
dc.contributor.author | Evans, D. Gareth; orcid: 0000-0002-8482-5784; email: Gareth.Evans@mft.nhs.uk | |
dc.contributor.author | Warren, Ruth M. L.; email: rmlw2@cam.ac.uk | |
dc.contributor.author | Howell, Anthony; email: Anthony.Howell@manchester.ac.uk | |
dc.contributor.author | Harvie, Michelle; orcid: 0000-0001-9761-3089; email: michelle.harvie@manchester.ac.uk | |
dc.date.accessioned | 2021-07-01T02:12:26Z | |
dc.date.available | 2021-07-01T02:12:26Z | |
dc.date.issued | 2021-06-29 | |
dc.identifier | https://chesterrep.openrepository.com/bitstream/handle/10034/625102/cancers-13-03245.pdf?sequence=2 | |
dc.identifier | https://chesterrep.openrepository.com/bitstream/handle/10034/625102/additional-files.zip?sequence=3 | |
dc.identifier | https://chesterrep.openrepository.com/bitstream/handle/10034/625102/cancers-13-03245.xml?sequence=4 | |
dc.identifier.citation | Cancers, volume 13, issue 13, page e3245 | |
dc.identifier.uri | http://hdl.handle.net/10034/625102 | |
dc.description | From MDPI via Jisc Publications Router | |
dc.description | History: accepted 2021-06-18, pub-electronic 2021-06-29 | |
dc.description | Publication status: Published | |
dc.description | Funder: Cancer Research UK; Grant(s): C569/A16891, IS-BRC-1215-20007 | |
dc.description.abstract | We evaluated the association between short-term change in body mass index (BMI) and breast density during a 1 year weight-loss intervention (Manchester, UK). We included 65 premenopausal women (35–45 years, ≥7 kg adult weight gain, family history of breast cancer). BMI and breast density (semi-automated area-based, automated volume-based) were measured at baseline, 1 year, and 2 years after study entry (1 year post intervention). Cross-sectional (between-women) and short-term change (within-women) associations between BMI and breast density were measured using repeated-measures correlation coefficients and multivariable linear mixed models. BMI was positively correlated with dense volume between-women (r = 0.41, 95%CI: 0.17, 0.61), but less so within-women (r = 0.08, 95%CI: −0.16, 0.28). There was little association with dense area (between-women r = −0.12, 95%CI: −0.38, 0.16; within-women r = 0.01, 95%CI: −0.24, 0.25). BMI and breast fat were positively correlated (volume: between r = 0.77, 95%CI: 0.69, 0.84, within r = 0.58, 95%CI: 0.36, 0.75; area: between r = 0.74, 95%CI: 0.63, 0.82, within r = 0.45, 95%CI: 0.23, 0.63). Multivariable models reported similar associations. Exploratory analysis suggested associations between BMI gain from 20 years and density measures (standard deviation change per +5 kg/m2 BMI: dense area: +0.61 (95%CI: 0.12, 1.09); fat volume: −0.31 (95%CI: −0.62, 0.00)). Short-term BMI change is likely to be positively associated with breast fat, but we found little association with dense tissue, although power was limited by small sample size. | |
dc.language | en | |
dc.publisher | MDPI | |
dc.rights | Licence for this article: https://creativecommons.org/licenses/by/4.0/ | |
dc.source | eissn: 2072-6694 | |
dc.subject | mammographic density | |
dc.subject | body mass index | |
dc.subject | weight loss | |
dc.subject | breast cancer risk | |
dc.subject | breast cancer prevention | |
dc.subject | premenopausal | |
dc.title | The Relationship between Body Mass Index and Mammographic Density during a Premenopausal Weight Loss Intervention Study | |
dc.type | article | |
dc.date.updated | 2021-07-01T02:12:26Z | |
dc.date.accepted | 2021-06-18 |