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dc.contributor.authorAderemi, Adewale Victor; email: adewale.aderemi@postgrad.manchester.ac.uk
dc.contributor.authorAyeleso, Ademola Olabode; email: ademola.ayeleso@adelekeuniversity.edu.ng
dc.contributor.authorOyedapo, Oluboade Oluokun; email: ooyedapo@yahoo.co.uk
dc.contributor.authorMukwevho, Emmanuel; orcid: 0000-0001-8800-955X; email: emmanuel.mukwevho@nwu.ac.za
dc.date.accessioned2021-06-29T00:31:07Z
dc.date.available2021-06-29T00:31:07Z
dc.date.issued2021-06-25
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/625072/metabolites-11-00418.pdf?sequence=2
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/625072/additional-files.zip?sequence=3
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/625072/metabolites-11-00418.xml?sequence=4
dc.identifier.citationMetabolites, volume 11, issue 7, page e418
dc.identifier.urihttp://hdl.handle.net/10034/625072
dc.descriptionFrom MDPI via Jisc Publications Router
dc.descriptionHistory: accepted 2021-06-23, pub-electronic 2021-06-25
dc.descriptionPublication status: Published
dc.description.abstractMetabolomics is a branch of ‘omics’ sciences that utilises a couple of analytical tools for the identification of small molecules (metabolites) in a given sample. The overarching goal of metabolomics is to assess these metabolites quantitatively and qualitatively for their diagnostic, therapeutic, and prognostic potentials. Its use in various aspects of life has been documented. We have also published, howbeit in animal models, a few papers where metabolomic approaches were used in the study of metabolic disorders, such as metabolic syndrome, diabetes, and obesity. As the goal of every research is to benefit humankind, the purpose of this review is to provide insights into the applicability of metabolomics in medicine vis-à-vis its role in biomarker discovery for disease diagnosis and management. Here, important biomarkers with proven diagnostic and therapeutic relevance in the management of disease conditions, such as Alzheimer’s disease, dementia, Parkinson’s disease, inborn errors of metabolism (IEM), diabetic retinopathy, and cardiovascular disease, are noted. The paper also discusses a few reasons why most metabolomics-based laboratory discoveries are not readily translated to the clinic and how these could be addressed going forward.
dc.languageen
dc.publisherMDPI
dc.rightsLicence for this article: https://creativecommons.org/licenses/by/4.0/
dc.sourceeissn: 2218-1989
dc.subjectmetabolomics
dc.subjectmetabolites
dc.subjectbiomarkers
dc.subjectanalytical tools
dc.subjectdiseases
dc.subjectdiabetes
dc.subjectobesity
dc.titleMetabolomics: A Scoping Review of Its Role as a Tool for Disease Biomarker Discovery in Selected Non-Communicable Diseases
dc.typearticle
dc.date.updated2021-06-29T00:31:07Z
dc.date.accepted2021-06-23


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