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dc.contributor.authorJenkins, Stephen J.; email: stephen.jenkins@ed.ac.uk
dc.contributor.authorAllen, Judith E.; email: judi.allen@manchester.ac.uk
dc.date.accessioned2021-06-27T16:18:49Z
dc.date.available2021-06-27T16:18:49Z
dc.date.issued2021-06-27
dc.date.submitted2021-03-02
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/625059/eji.202048881.pdf?sequence=2
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/625059/eji.202048881.xml?sequence=3
dc.identifier.citationEuropean Journal of Immunology
dc.identifier.urihttp://hdl.handle.net/10034/625059
dc.descriptionFrom Wiley via Jisc Publications Router
dc.descriptionHistory: received 2021-03-02, rev-recd 2021-03-02, accepted 2021-06-08, pub-electronic 2021-06-27
dc.descriptionArticle version: VoR
dc.descriptionPublication status: Published
dc.descriptionFunder: the Medical Research Council UK; Grant(s): MR/K01207X/2, MR/L008076/1
dc.descriptionFunder: the Wellcome Trust; Grant(s): 106898/A/15/Z
dc.description.abstractAbstract: The term ‘macrophage’ encompasses tissue cells that typically share dependence on the same transcriptional regulatory pathways (e.g. the transcription factor PU.1) and growth factors (e.g. CSF1/IL‐34). They share a core set of functions that largely arise from a uniquely high phagocytic capacity manifest in their ability to clear dying cells, pathogens and scavenge damaged, toxic or modified host molecules. However, macrophages demonstrate a remarkable degree of tissue‐specific functionality and have diverse origins that vary by tissue site and inflammation status. With our understanding of this diversity has come an appreciation of the longevity and replicative capacity of tissue‐resident macrophages and thus the realisation that macrophages may persist through tissue perturbations and inflammatory events with important consequences for cell function. Here, we discuss our current understanding of the parameters that regulate macrophage survival and function, focusing on the relative importance of the tissue environment versus cell‐intrinsic factors, such as origin, how long a cell has been resident within a tissue and prior history of activation. Thus, we reconsider the view of macrophages as wholly plastic cells and raise many unanswered questions about the relative importance of cell life‐history versus environment in macrophage programming and function.
dc.languageen
dc.rightsLicence for VoR version of this article: http://creativecommons.org/licenses/by/4.0/
dc.sourceissn: 0014-2980
dc.sourceissn: 1521-4141
dc.subjectReview|Basic
dc.subjectHighlights
dc.subjectCellular immunology
dc.subjectDendritic cells
dc.subjectInfection
dc.subjectMacrophages
dc.subjectMonocytes
dc.titleThe expanding world of tissue‐resident macrophages
dc.typearticle
dc.date.updated2021-06-27T16:18:49Z
dc.date.accepted2021-06-08


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