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dc.contributor.authorWulandari, Laksmi
dc.contributor.authorHamidah, Berliana
dc.contributor.authorPakpahan, Cennikon
dc.contributor.authorDamayanti, Nevy Shinta
dc.contributor.authorKurniati, Neneng Dewi
dc.contributor.authorAdiatmaja, Christophorus Oetama
dc.contributor.authorWigianita, Monica Rizky
dc.contributor.authorSoedarsono
dc.contributor.authorHusada, Dominicus
dc.contributor.authorTinduh, Damayanti
dc.contributor.authorPrakoeswa, Cita Rosita Sigit
dc.contributor.authorEndaryanto, Anang
dc.contributor.authorPuspaningsih, Ni Nyoman Tri
dc.contributor.authorMori, Yasuko
dc.contributor.authorLusida, Maria Inge
dc.contributor.authorShimizu, Kazufumi
dc.contributor.authorOceandy, Delvac; orcid: 0000-0002-6242-6491; email: delvac.oceandy@manchester.ac.uk
dc.date.accessioned2021-06-19T01:16:41Z
dc.date.available2021-06-19T01:16:41Z
dc.date.issued2021-05-17
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/624993/article.pdf?sequence=2
dc.identifier.citationHuman genomics, volume 15, issue 1, page 29
dc.identifier.urihttp://hdl.handle.net/10034/624993
dc.descriptionFrom Europe PMC via Jisc Publications Router
dc.descriptionHistory: ppub 2021-05-01, epub 2021-05-17
dc.descriptionPublication status: Published
dc.descriptionFunder: Universitas Airlangga; Grant(s): Mandate Reserach Grant COVID-19
dc.description.abstract<h4>Background</h4>Coronavirus disease 2019 (COVID-19) is a global health problem that causes millions of deaths worldwide. The clinical manifestation of COVID-19 widely varies from asymptomatic infection to severe pneumonia and systemic inflammatory disease. It is thought that host genetic variability may affect the host's response to the virus infection and thus cause severity of the disease. The SARS-CoV-2 virus requires interaction with its receptor complex in the host cells before infection. The transmembrane protease serine 2 (TMPRSS2) has been identified as one of the key molecules involved in SARS-CoV-2 virus receptor binding and cell invasion. Therefore, in this study, we investigated the correlation between a genetic variant within the human TMPRSS2 gene and COVID-19 severity and viral load.<h4>Results</h4>We genotyped 95 patients with COVID-19 hospitalised in Dr Soetomo General Hospital and Indrapura Field Hospital (Surabaya, Indonesia) for the TMPRSS2 p.Val160Met polymorphism. Polymorphism was detected using a TaqMan assay. We then analysed the association between the presence of the genetic variant and disease severity and viral load. We did not observe any correlation between the presence of TMPRSS2 genetic variant and the severity of the disease. However, we identified a significant association between the p.Val160Met polymorphism and the SARS-CoV-2 viral load, as estimated by the Ct value of the diagnostic nucleic acid amplification test. Furthermore, we observed a trend of association between the presence of the C allele and the mortality rate in patients with severe COVID-19.<h4>Conclusion</h4>Our data indicate a possible association between TMPRSS2 p.Val160Met polymorphism and SARS-CoV-2 infectivity and the outcome of COVID-19.
dc.languageeng
dc.rightsLicence for this article: cc by
dc.sourceissn: 1473-9542
dc.sourceessn: 1479-7364
dc.sourcenlmid: 101202210
dc.subjectPolymorphism
dc.subjectTmprss2
dc.subjectCovid-19
dc.subjectHumans
dc.subjectGenetic Predisposition to Disease
dc.subjectSerine Endopeptidases
dc.subjectViral Load
dc.subjectCross-Sectional Studies
dc.subjectGene Frequency
dc.subjectGenotype
dc.subjectPolymorphism, Single Nucleotide
dc.subjectAlleles
dc.subjectAdult
dc.subjectMiddle Aged
dc.subjectIndonesia
dc.subjectFemale
dc.subjectMale
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.titleInitial study on TMPRSS2 p.Val160Met genetic variant in COVID-19 patients.
dc.typearticle
dc.date.updated2021-06-19T01:16:41Z


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