Show simple item record

dc.contributor.authorGooding, Patricia A.; orcid: 0000-0002-7458-4462; email: patricia.gooding@manchester.ac.uk
dc.contributor.authorPratt, Daniel
dc.contributor.authorAwenat, Yvonne
dc.contributor.authorDrake, Richard
dc.contributor.authorElliott, Rachel
dc.contributor.authorEmsley, Richard
dc.contributor.authorHuggett, Charlotte
dc.contributor.authorJones, Steven
dc.contributor.authorKapur, Navneet
dc.contributor.authorLobban, Fiona
dc.contributor.authorPeters, Sarah
dc.contributor.authorHaddock, Gillian
dc.date.accessioned2021-06-17T09:59:11Z
dc.date.available2021-06-17T09:59:11Z
dc.date.issued2020-06-16
dc.date.submitted2020-04-21
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/624965/12888_2020_Article_2697_nlm.xml?sequence=2
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/624965/12888_2020_Article_2697.pdf?sequence=3
dc.identifier.citationBMC Psychiatry, volume 20, issue 1, page 306
dc.identifier.urihttp://hdl.handle.net/10034/624965
dc.descriptionFrom Springer Nature via Jisc Publications Router
dc.descriptionHistory: received 2020-04-21, accepted 2020-05-27, registration 2020-05-28, pub-electronic 2020-06-16, online 2020-06-16, collection 2020-12
dc.descriptionPublication status: Published
dc.descriptionFunder: Efficacy and Mechanism Evaluation Programme; doi: http://dx.doi.org/10.13039/501100001922; Grant(s): 13/161/25
dc.description.abstractAbstract: Background: Suicide is a leading cause of death globally. Suicide deaths are elevated in those experiencing severe mental health problems, including schizophrenia. Psychological talking therapies are a potentially effective means of alleviating suicidal thoughts, plans, and attempts. However, talking therapies need to i) focus on suicidal experiences directly and explicitly, and ii) be based on testable psychological mechanisms. The Cognitive AppRoaches to coMbatting Suicidality (CARMS) project is a Randomised Controlled Trial (RCT) which aims to investigate both the efficacy and the underlying mechanisms of a psychological talking therapy for people who have been recently suicidal and have non-affective psychosis. Methods: The CARMS trial is a two-armed single-blind RCT comparing a psychological talking therapy (Cognitive Behavioural Suicide Prevention for psychosis [CBSPp]) plus Treatment As Usual (TAU) with TAU alone. There are primary and secondary suicidality outcome variables, plus mechanistic, clinical, and health economic outcomes measured over time. The primary outcome is a measure of suicidal ideation at 6 months after baseline. The target sample size is 250, with approximately 125 randomised to each arm of the trial, and an assumption of up to 25% attrition. Hence, the overall recruitment target is up to 333. An intention to treat analysis will be used with primary stratification based on National Health Service (NHS) recruitment site and antidepressant prescription medication. Recruitment will be from NHS mental health services in the North West of England, UK. Participants must be 18 or over; be under the care of mental health services; have mental health problems which meet ICD-10 non-affective psychosis criteria; and have experienced self-reported suicidal thoughts, plans, and/or attempts in the 3 months prior to recruitment. Nested qualitative work will investigate the pathways to suicidality, experiences of the therapy, and identify potential implementation challenges beyond a trial setting as perceived by numerous stake-holders. Discussion: This trial has important implications for countering suicidal experiences for people with psychosis. It will provide definitive evidence about the efficacy of the CBSPp therapy; the psychological mechanisms which lead to suicidal experiences; and provide an understanding of what is required to implement the intervention into services should it be efficacious. Trial registration: ClinicalTrials.gov (NCT03114917), 14th April 2017. ISRCTN (reference ISRCTN17776666 https://doi.org/10.1186/ISRCTN17776666); 5th June 2017). Registration was recorded prior to participant recruitment commencing.
dc.languageen
dc.publisherBioMed Central
dc.rightsLicence for this article: http://creativecommons.org/licenses/by/4.0/
dc.sourceeissn: 1471-244X
dc.subjectStudy Protocol
dc.subjectCauses, treatment and prevention of suicide
dc.subjectSuicide
dc.subjectSuicidal thoughts and behaviours
dc.subjectPsychological interventions
dc.subjectCognitive therapy
dc.subjectPsychosis
dc.subjectSchizophrenia
dc.subjectPsychological suicide mechanisms
dc.subjectRandomised controlled trial
dc.titleA psychological intervention for suicide applied to non-affective psychosis: the CARMS (Cognitive AppRoaches to coMbatting Suicidality) randomised controlled trial protocol
dc.typearticle
dc.date.updated2021-06-17T09:59:10Z
dc.date.accepted2020-05-27


Files in this item

Thumbnail
Name:
12888_2020_Article_2697_nlm.xml
Size:
175.8Kb
Format:
XML
Thumbnail
Name:
12888_2020_Article_2697.pdf
Size:
826.6Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record