Show simple item record

dc.contributor.authorNicolaou, Sonia T
dc.contributor.authorHebditch, Max; orcid: 0000-0002-5424-193X
dc.contributor.authorJonathan, Owen J
dc.contributor.authorVerma, Chandra S
dc.contributor.authorWarwicker, Jim; orcid: 0000-0002-1302-0815; email: jim.warwicker@manchester.ac.uk
dc.date.accessioned2021-06-13T01:05:53Z
dc.date.available2021-06-13T01:05:53Z
dc.date.issued2021-05-11
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/624928/article.pdf?sequence=2
dc.identifier.citationScientific reports, volume 11, issue 1, page 9930
dc.identifier.urihttp://hdl.handle.net/10034/624928
dc.descriptionFrom Europe PMC via Jisc Publications Router
dc.descriptionHistory: ppub 2021-05-01, epub 2021-05-11
dc.descriptionPublication status: Published
dc.descriptionFunder: Engineering and Physical Sciences Research Council; Grant(s): EP/N024796/1
dc.descriptionFunder: Agency for Science, Technology and Research; Grant(s): IDs H17/01/a0/010
dc.description.abstractCharge is a key determinant of intrinsically disordered protein (IDP) and intrinsically disordered region (IDR) properties. IDPs and IDRs are enriched in sites of phosphorylation, which alters charge. Visualizing the degree to which phosphorylation modulates the charge profile of a sequence would assist in the functional interpretation of IDPs and IDRs. PhosIDP is a web tool that shows variation of charge and fold propensity upon phosphorylation. In combination with the displayed location of protein domains, the information provided by the web tool can lead to functional inferences for the consequences of phosphorylation. IDRs are components of many proteins that form biological condensates. It is shown that IDR charge, and its modulation by phosphorylation, is more tightly controlled for proteins that are essential for condensate formation than for those present in condensates but inessential.
dc.languageeng
dc.rightsLicence for this article: cc by
dc.sourceissn: 2045-2322
dc.sourceessn: 2045-2322
dc.sourcenlmid: 101563288
dc.titlePhosIDP: a web tool to visualize the location of phosphorylation sites in disordered regions.
dc.typearticle
dc.date.updated2021-06-13T01:05:52Z


Files in this item

Thumbnail
Name:
article.pdf
Size:
1.271Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record