Show simple item record

dc.contributor.authorLeventea, Eleni; orcid: 0000-0002-7213-1048; email: eleni.leventea@addenbrookes.nhs.uk
dc.contributor.authorHarkness, Elaine F.; orcid: 0000-0001-6625-7739; email: Elaine.F.Harkness@manchester.ac.uk
dc.contributor.authorBrentnall, Adam R.; email: a.brentnall@qmul.ac.uk
dc.contributor.authorHowell, Anthony; email: Anthony.Howell@manchester.ac.uk
dc.contributor.authorEvans, D. Gareth; orcid: 0000-0002-8482-5784; email: Gareth.Evans@mft.nhs.uk
dc.contributor.authorHarvie, Michelle; orcid: 0000-0001-9761-3089; email: michelle.harvie@manchester.ac.uk
dc.date.accessioned2021-06-01T22:14:26Z
dc.date.available2021-06-01T22:14:26Z
dc.date.issued2021-05-31
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/624807/cancers-13-02710.pdf?sequence=2
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/624807/additional-files.zip?sequence=3
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/624807/cancers-13-02710.xml?sequence=4
dc.identifier.citationCancers, volume 13, issue 11, page e2710
dc.identifier.urihttp://hdl.handle.net/10034/624807
dc.descriptionFrom MDPI via Jisc Publications Router
dc.descriptionHistory: accepted 2021-05-25, pub-electronic 2021-05-31
dc.descriptionPublication status: Published
dc.description.abstractMenopausal hormone therapy (MHT) has an attenuated effect on breast cancer (BC) risk amongst heavier women, but there are few data on a potential interaction with early adulthood body mass index (at age 20 years) and age of first pregnancy. We studied 56,489 women recruited to the PROCAS (Predicting Risk of Cancer at Screening) study in Manchester UK, 2009-15. Cox regression models estimated the effect of reported MHT use at entry on breast cancer (BC) risk, and potential interactions with a. self-reported current body mass index (BMI), b. BMI aged 20 and c. First pregnancy >30 years or nulliparity compared with first pregnancy 30 years. Analysis was adjusted for age, height, family history, age of menarche and menopause, menopausal status, oophorectomy, ethnicity, self-reported exercise and alcohol. With median follow up of 8 years, 1663 breast cancers occurred. BC risk was elevated amongst current users of combined MHT compared to never users (Hazard ratioHR 1.64, 95% CI 1.32–2.03), risk was higher than for oestrogen only users (HR 1.03, 95% CI 0.79–1.34). Risk of current MHT was attenuated by current BMI (interaction HR 0.80, 95% CI 0.65–0.99) per 5 unit increase in BMI. There was little evidence of an interaction between MHT use, breast cancer risk and early and current BMI or with age of first pregnancy.
dc.languageen
dc.publisherMDPI
dc.rightsLicence for this article: https://creativecommons.org/licenses/by/4.0/
dc.sourceeissn: 2072-6694
dc.subjectmenopausal hormone therapy
dc.subjectbreast cancer risk
dc.subjectBMI
dc.subjectearly BMI
dc.subjectage of pregnancy
dc.titleIs Breast Cancer Risk Associated with Menopausal Hormone Therapy Modified by Current or Early Adulthood BMI or Age of First Pregnancy?
dc.typearticle
dc.date.updated2021-06-01T22:14:26Z
dc.date.accepted2021-05-25


Files in this item

Thumbnail
Name:
cancers-13-02710.pdf
Size:
461.4Kb
Format:
PDF
Thumbnail
Name:
additional-files.zip
Size:
388.4Kb
Format:
Unknown
Thumbnail
Name:
cancers-13-02710.xml
Size:
11.33Kb
Format:
XML

This item appears in the following Collection(s)

Show simple item record