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dc.contributor.authorHughes, Stephen F.; orcid: 0000-0001-6558-9037; email: Stephen.hughes6@wales.nhs.uk
dc.contributor.authorJones, Nathan
dc.contributor.authorThomas-Wright, Samantha J.
dc.contributor.authorBanwell, Joseph
dc.contributor.authorMoyes, Alyson J.
dc.contributor.authorShergill, Iqbal
dc.date.accessioned2021-06-01T16:42:39Z
dc.date.available2021-06-01T16:42:39Z
dc.date.issued2020-06-01
dc.date.submitted2020-04-21
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/624804/40001_2020_Article_417.pdf?sequence=2
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/624804/40001_2020_Article_417_nlm.xml?sequence=3
dc.identifier.citationEuropean Journal of Medical Research, volume 25, issue 1, page 18
dc.identifier.urihttp://hdl.handle.net/10034/624804
dc.descriptionFrom Springer Nature via Jisc Publications Router
dc.descriptionHistory: received 2020-04-21, accepted 2020-05-27, registration 2020-05-27, pub-electronic 2020-06-01, online 2020-06-01, collection 2020-12
dc.descriptionPublication status: Published
dc.descriptionFunder: Institute of Biomedical Science; doi: http://dx.doi.org/10.13039/501100000825
dc.description.abstractAbstract: Background: The number of patients undergoing shock wave lithotripsy (SWL) for kidney stones is increasing annually, and as such the development of post-operative complications, such as haematuria and acute kidney injury (AKI) following SWL, is likely to increase. The aim of the study was to evaluate changes in routine blood and novel biomarkers following SWL, for the treatment of kidney stones. Methods: Twelve patients undergoing SWL for solitary unilateral kidney stones were recruited. From patients (8 males and 4 females) aged between 31 and 72 years (median 43 years), venous blood samples were collected pre-operatively (baseline), at 30, 120 and 240 min post-operatively. Routine blood tests were performed using a Sysmex XE-5000, and Beckman Coulter AU5800 and AU680 analysers. NGAL, IL-18, IL-6, TNF-α, IL-10 and IL-8 concentrations were determined using commercially available ELISA kits. Results: Significant (p ≤ 0.05) changes were observed in several blood parameters following SWL. NGAL concentration significantly increased, with values peaking at 30 min post-treatment (p = 0.033). Although IL-18 concentration increased, these changes were not significant (p = 0.116). IL-6 revealed a statistically significant rise from pre-operative up to 4 h post-operatively (p < 0.001), whilst TNF-α significantly increased, peaking at 30 min post-SWL (p = 0.05). There were no significant changes to IL-10 and IL-8 concentrations post-SWL (p > 0.05). Conclusions: Changes to routine blood tests and specific biomarkers, in the future, may be more useful for clinicians. In turn, identification of a panel of biomarkers could provide valuable data on “normal” physiological response after lithotripsy. Ultimately, studies could be expanded to identify or predict those patients at increased risk of developing post-operative complications, such as acute kidney injury or. These studies, however, need validating involving larger cohorts.
dc.languageen
dc.publisherBioMed Central
dc.rightsLicence for this article: http://creativecommons.org/licenses/by/4.0/
dc.sourceeissn: 2047-783X
dc.subjectResearch
dc.subjectShock wave lithotripsy (SWL)
dc.subjectBiomarkers
dc.subjectKidney stones
dc.subjectInflammation
dc.subjectRoutine blood tests
dc.subjectAcute kidney injury (AKI)
dc.titleShock wave lithotripsy, for the treatment of kidney stones, results in changes to routine blood tests and novel biomarkers: a prospective clinical pilot-study
dc.typearticle
dc.date.updated2021-06-01T16:42:39Z
dc.date.accepted2020-05-27


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