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dc.contributor.authorAdams, Benjamin
dc.contributor.authorJacocks, Lauren
dc.contributor.authorGuo, Hui; orcid: 0000-0003-0282-6933; email: hui.guo@manchester.ac.uk
dc.date.accessioned2021-05-29T15:29:12Z
dc.date.available2021-05-29T15:29:12Z
dc.date.issued2020-05-29
dc.date.submitted2020-03-06
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/624756/12872_2020_Article_1542_nlm.xml?sequence=2
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/624756/12872_2020_Article_1542.pdf?sequence=3
dc.identifier.citationBMC Cardiovascular Disorders, volume 20, issue 1, page 258
dc.identifier.urihttp://hdl.handle.net/10034/624756
dc.descriptionFrom Springer Nature via Jisc Publications Router
dc.descriptionHistory: received 2020-03-06, accepted 2020-05-20, registration 2020-05-21, pub-electronic 2020-05-29, online 2020-05-29, collection 2020-12
dc.descriptionPublication status: Published
dc.descriptionFunder: Medical Research Council; doi: http://dx.doi.org/10.13039/501100000265; Grant(s): MR/N01375/1
dc.description.abstractAbstract: Background: BMI has been implicated as a risk factor for heart disease as a whole in multiple studies. Heart attack is one of the common complications of this disease. The aim of this study is to explore if elevated level of BMI causes an increase in the risk of heart attacks. Methods: We used two Mendelian randomisation (MR) methods: inverse variance weighted estimation and robust adjusted profile score (RAPS) on the basis of summary data of adulthood BMI from Genetic Investigation of Anthropometric Traits consortium and heart attack data from the UK Biobank. BMI associated single nucleotide polymorphisms (SNPs) were used as instrumental variables. Results: Seventy-two independent SNPs were associated with BMI (P < 5 × 10− 8). Using these SNPs as instruments, BMI was found to be causally associated with heart attacks in inverse variance weighted MR analysis. The risk of heart attacks increased by 0.8% per 1-SD (or 4.5 kg/m2) increase in BMI (OR = 1.008 with 95% CI (1.003, 1.012), P = 0.001). RAPS provided concordant results (OR = 1.007 with 95% CI (1.002, 1.012), P = 0.004). Conclusions: This current study is the first to use MR to investigate causal relationship between BMI and heart attacks. Our findings suggest that high level of BMI may cause increased risk of heart attacks.
dc.languageen
dc.publisherBioMed Central
dc.rightsLicence for this article: http://creativecommons.org/licenses/by/4.0/
dc.sourceeissn: 1471-2261
dc.subjectResearch Article
dc.subjectHypertension and Cardiovascular Risk
dc.subjectBMI
dc.subjectHeart attacks
dc.subjectCausal relationship
dc.subjectMendelian randomisation
dc.titleHigher BMI is linked to an increased risk of heart attacks in European adults: a Mendelian randomisation study
dc.typearticle
dc.date.updated2021-05-29T15:29:12Z
dc.date.accepted2020-05-20


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