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AbstractTo determine the variability, and preferred values, for normal liver longitudinal water proton relaxation rate R in the published literature. Values of mean R and between-subject variance were obtained from literature searching. Weighted means were fitted to a heuristic and to a model. After exclusions, 116 publications (143 studies) remained, representing apparently normal liver in 3392 humans, 99 mice and 249 rats. Seventeen field strengths were included between 0.04 T and 9.4 T. Older studies tended to report higher between-subject coefficients of variation (CoV), but for studies published since 1992, the median between-subject CoV was 7.4%, and in half of those studies, measured R deviated from model by 8.0% or less. The within-study between-subject CoV incorporates repeatability error and true between-subject variation. Between-study variation also incorporates between-population variation, together with bias from interactions between methodology and physiology. While quantitative relaxometry ultimately requires validation with phantoms and analysis of propagation of errors, this survey allows investigators to compare their own R and variability values with the range of existing literature.
CitationMagma (New York, N.Y.)
DescriptionFrom PubMed via Jisc Publications Router
History: received 2021-01-20, revised 2021-04-05, accepted 2021-04-27
Publication status: aheadofprint
Funder: Innovative Medicines Initiatives 2 Joint Undertaking; Grant(s): 116106 (IB4SD-TRISTAN)