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dc.contributor.authorGuan, Wenzheng
dc.contributor.authorXia, Maosheng
dc.contributor.authorJi, Ming
dc.contributor.authorChen, Beina
dc.contributor.authorLi, Shuai
dc.contributor.authorZhang, Manman
dc.contributor.authorLiang, Shanshan
dc.contributor.authorChen, Binjie
dc.contributor.authorGong, Wenliang
dc.contributor.authorDong, Chengyi
dc.contributor.authorWen, Gehua
dc.contributor.authorZhan, Xiaoni
dc.contributor.authorZhang, Dianjun
dc.contributor.authorLi, Xinyu
dc.contributor.authorZhou, Yuefei
dc.contributor.authorGuan, Dawei; orcid: 0000-0002-9439-6557; email: dwguan@cmu.edu.cn
dc.contributor.authorVerkhratsky, Alexei; orcid: 0000-0003-2592-9898; email: alexej.verkhratsky@manchester.ac.uk
dc.contributor.authorLi, Baoman; orcid: 0000-0002-3959-9570; email: bmli@cmu.edu.cn
dc.date.accessioned2021-05-20T16:39:41Z
dc.date.available2021-05-20T16:39:41Z
dc.date.issued2021-05-05
dc.date.submitted2020-09-18
dc.identifierpubmed: 33953326
dc.identifierdoi: 10.1038/s42003-021-02060-x
dc.identifierpii: 10.1038/s42003-021-02060-x
dc.identifierpmc: PMC8100120
dc.identifier.citationCommunications biology, volume 4, issue 1, page 525
dc.identifier.urihttp://hdl.handle.net/10034/624632
dc.descriptionFrom PubMed via Jisc Publications Router
dc.descriptionHistory: received 2020-09-18, accepted 2021-03-30
dc.descriptionPublication status: epublish
dc.descriptionFunder: National Natural Science Foundation of China (National Science Foundation of China); Grant(s): 81871852
dc.description.abstractIron is the fundamental element for numerous physiological functions. Plasmalemmal divalent metal ion transporter 1 (DMT1) is responsible for cellular uptake of ferrous (Fe ), whereas transferrin receptors (TFR) carry transferrin (TF)-bound ferric (Fe ). In this study we performed detailed analysis of the action of Fe ions on cytoplasmic free calcium ion concentration ([Ca ] ) in astrocytes. Administration of Fe or Fe in μM concentrations evoked [Ca ] in astrocytes in vitro and in vivo. Iron ions trigger increase in [Ca ] through two distinct molecular cascades. Uptake of Fe by DMT1 inhibits astroglial Na -K -ATPase, which leads to elevation in cytoplasmic Na concentration, thus reversing Na /Ca exchanger and thereby generating Ca influx. Uptake of Fe by TF-TFR stimulates phospholipase C to produce inositol 1,4,5-trisphosphate (InsP ), thus triggering InsP receptor-mediated Ca release from endoplasmic reticulum. In summary, these findings reveal the mechanisms of iron-induced astrocytic signalling operational in conditions of iron overload.
dc.languageeng
dc.sourceeissn: 2399-3642
dc.titleIron induces two distinct Ca
dc.typearticle
dc.date.updated2021-05-20T16:39:41Z
dc.date.accepted2021-03-30


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