Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia.
AuthorsHayter, Edward A; orcid: 0000-0001-9996-7198
Wehrens, Sophie M T; orcid: 0000-0001-7523-1514
Van Dongen, Hans P A; orcid: 0000-0002-4678-2971
Stangherlin, Alessandra; orcid: 0000-0001-7296-1183
Barron, Nichola J
Venetucci, Luigi A
Neill, John S O'; orcid: 0000-0003-2204-6096
Brown, Timothy M
Skene, Debra J
Trafford, Andrew W; orcid: 0000-0002-2770-445X
Bechtold, David A; orcid: 0000-0001-8676-8704; email: firstname.lastname@example.org
MetadataShow full item record
AbstractElectrical activity in the heart exhibits 24-hour rhythmicity, and potentially fatal arrhythmias are more likely to occur at specific times of day. Here, we demonstrate that circadian clocks within the brain and heart set daily rhythms in sinoatrial (SA) and atrioventricular (AV) node activity, and impose a time-of-day dependent susceptibility to ventricular arrhythmia. Critically, the balance of circadian inputs from the autonomic nervous system and cardiomyocyte clock to the SA and AV nodes differ, and this renders the cardiac conduction system sensitive to decoupling during abrupt shifts in behavioural routine and sleep-wake timing. Our findings reveal a functional segregation of circadian control across the heart's conduction system and inherent susceptibility to arrhythmia.
CitationNature communications, volume 12, issue 1, page 2472
DescriptionFrom PubMed via Jisc Publications Router
History: received 2020-05-28, accepted 2021-03-26
Publication status: epublish
Funder: Medical Research Council; Grant(s): MC_UP_1201/4
Funder: NCI NIH HHS; Grant(s): R21 CA227381
Funder: Biotechnology and Biological Sciences Research Council; Grant(s): BB/J017744/1, BB/I018654/1, BB/I019405/1
Funder: NIEHS NIH HHS; Grant(s): R01 ES030113
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