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dc.contributor.authorBudden, Timothy
dc.contributor.authorGaudy-Marqueste, Caroline
dc.contributor.authorPorter, Andrew; orcid: 0000-0002-3353-7002
dc.contributor.authorKay, Emily
dc.contributor.authorGurung, Shilpa
dc.contributor.authorEarnshaw, Charles H.; orcid: 0000-0002-7926-8506
dc.contributor.authorRoeck, Katharina
dc.contributor.authorCraig, Sarah; orcid: 0000-0003-1928-582X
dc.contributor.authorTraves, Víctor
dc.contributor.authorKrutmann, Jean; orcid: 0000-0001-8433-1517
dc.contributor.authorMuller, Patricia
dc.contributor.authorMotta, Luisa
dc.contributor.authorZanivan, Sara; orcid: 0000-0002-9880-9099
dc.contributor.authorMalliri, Angeliki; orcid: 0000-0001-6848-090X
dc.contributor.authorFurney, Simon J.; orcid: 0000-0002-8920-6800
dc.contributor.authorNagore, Eduardo; orcid: 0000-0003-3433-8707
dc.contributor.authorVirós, Amaya; orcid: 0000-0001-5177-5015; email: Amaya.viros@cruk.manchester.ac.uk
dc.date.accessioned2021-05-20T16:38:04Z
dc.date.available2021-05-20T16:38:04Z
dc.date.issued2021-05-12
dc.date.submitted2020-08-31
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/624547/41467_2021_22953_MOESM2_ESM.pdf?sequence=2
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/624547/41467_2021_Article_22953.pdf?sequence=3
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/624547/additional-files.zip?sequence=4
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/624547/41467_2021_22953_MOESM6_ESM.pdf?sequence=5
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/624547/41467_2021_22953_MOESM3_ESM.pdf?sequence=6
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/624547/41467_2021_22953_MOESM1_ESM.pdf?sequence=7
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/624547/41467_2021_Article_22953_nlm.xml?sequence=8
dc.identifier.citationNature Communications, volume 12, issue 1, page 2742
dc.identifier.urihttp://hdl.handle.net/10034/624547
dc.descriptionFrom Springer Nature via Jisc Publications Router
dc.descriptionHistory: received 2020-08-31, accepted 2021-04-08, registration 2021-04-11, online 2021-05-12, pub-electronic 2021-05-12, collection 2021-12
dc.descriptionPublication status: Published
dc.description.abstractAbstract: Ultraviolet radiation (UVR) damages the dermis and fibroblasts; and increases melanoma incidence. Fibroblasts and their matrix contribute to cancer, so we studied how UVR modifies dermal fibroblast function, the extracellular matrix (ECM) and melanoma invasion. We confirmed UVR-damaged fibroblasts persistently upregulate collagen-cleaving matrix metalloprotein-1 (MMP1) expression, reducing local collagen (COL1A1), and COL1A1 degradation by MMP1 decreased melanoma invasion. Conversely, inhibiting ECM degradation and MMP1 expression restored melanoma invasion. Primary cutaneous melanomas of aged humans show more cancer cells invade as single cells at the invasive front of melanomas expressing and depositing more collagen, and collagen and single melanoma cell invasion are robust predictors of poor melanoma-specific survival. Thus, primary melanomas arising over collagen-degraded skin are less invasive, and reduced invasion improves survival. However, melanoma-associated fibroblasts can restore invasion by increasing collagen synthesis. Finally, high COL1A1 gene expression is a biomarker of poor outcome across a range of primary cancers.
dc.languageen
dc.publisherNature Publishing Group UK
dc.rightsLicence for this article: http://creativecommons.org/licenses/by/4.0/
dc.sourceeissn: 2041-1723
dc.subjectArticle
dc.subject/631/67/1813/1634
dc.subject/692/4028/67/327
dc.subject/13/1
dc.subject/13/51
dc.subject/14/3
dc.subject/13/89
dc.subject/13/106
dc.subject/13/109
dc.subject/14/1
dc.subject/14/63
dc.subject/38
dc.subject/38/39
dc.subject/38/91
dc.subject/45/23
dc.subject/64/60
dc.subjectarticle
dc.titleUltraviolet light-induced collagen degradation inhibits melanoma invasion
dc.typearticle
dc.date.updated2021-05-20T16:38:04Z
dc.date.accepted2021-04-08


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