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dc.contributor.authorHalls, Daniel; orcid: 0000-0002-5372-3179
dc.contributor.authorLeslie, Monica
dc.contributor.authorLeppanen, Jenni
dc.contributor.authorSedgewick, Felicity
dc.contributor.authorSurguladze, Simon
dc.contributor.authorFonville, Leon
dc.contributor.authorLang, Katie
dc.contributor.authorSimic, Mima
dc.contributor.authorNicholls, Dasha
dc.contributor.authorWilliams, Steven
dc.contributor.authorTchanturia, Kate
dc.date.accessioned2021-04-02T01:02:33Z
dc.date.available2021-04-02T01:02:33Z
dc.date.issued2021-03-19
dc.date.submitted2020-05-15
dc.identifierpubmed: 33739540
dc.identifierdoi: 10.1002/hbm.25417
dc.identifier.citationHuman brain mapping
dc.identifier.urihttp://hdl.handle.net/10034/624424
dc.descriptionFrom PubMed via Jisc Publications Router
dc.descriptionHistory: received 2020-05-15, revised 2021-03-04, accepted 2021-03-08
dc.descriptionPublication status: aheadofprint
dc.descriptionFunder: Medical Research Council; Grant(s): MR/R004595/1, MR/S020381/1
dc.description.abstractSocial-emotional processing difficulties have been reported in Anorexia Nervosa (AN), yet the neural correlates remain unclear. Previous neuroimaging work is sparse and has not used functional connectivity paradigms to more fully explore the neural correlates of emotional difficulties. Fifty-seven acutely unwell AN (AAN) women, 60 weight-recovered AN (WR) women and 69 healthy control (HC) women categorised the gender of a series of emotional faces while undergoing Functional Magnetic Resonance Imaging. The mean age of the AAN group was 19.40 (2.83), WR 18.37 (3.59) and HC 19.37 (3.36). A whole brain and psychophysical interaction connectivity approach was used. Parameter estimates from significant clusters were extracted and correlated with clinical symptoms. Whilst no group level differences in whole brain activation were demonstrated, significant group level functional connectivity differences emerged. WR participants showed increased connectivity between the bilateral occipital face area and the cingulate, precentral gyri, superior, middle, medial and inferior frontal gyri compared to AAN and HC when viewing happy valenced faces. Eating disorder symptoms and parameter estimates were positively correlated. Our findings characterise the neural basis of social-emotional processing in a large sample of individuals with AN. [Abstract copyright: © 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.]
dc.languageeng
dc.sourceeissn: 1097-0193
dc.subjectanorexia nervosa
dc.subjectemotional faces
dc.subjectemotional processing
dc.subjectfunctional magnetic resonance imagining
dc.subjectpsychophysical interaction
dc.titleThe emotional face of anorexia nervosa: The neural correlates of emotional processing.
dc.typearticle
dc.date.updated2021-04-02T01:02:33Z
dc.date.accepted2021-03-08


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