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dc.contributor.authorJohnson, Louis D. V.; email: louisdvj@gmail.com
dc.contributor.authorPickard, Mark R.; email: m.pickard@chester.ac.uk
dc.contributor.authorJohnson, William E. B.; email: eustace.johnson@chester.ac.uk
dc.date.accessioned2021-03-18T03:07:43Z
dc.date.available2021-03-18T03:07:43Z
dc.date.issued2021-03-16
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/624358/biology-10-00230.pdf?sequence=2
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/624358/biology-10-00230.xml?sequence=3
dc.identifier.citationBiology, volume 10, issue 3, page e230
dc.identifier.urihttp://hdl.handle.net/10034/624358
dc.descriptionFrom MDPI via Jisc Publications Router
dc.descriptionHistory: accepted 2021-03-12, pub-electronic 2021-03-16
dc.descriptionPublication status: Published
dc.description.abstractAnimal models have been used in preclinical research to examine potential new treatments for spinal cord injury (SCI), including mesenchymal stem cell (MSC) transplantation. MSC transplants have been studied in early human trials. Whether the animal models represent the human studies is unclear. This systematic review and meta-analysis has examined the effects of MSC transplants in human and animal studies. Following searches of PubMed, Clinical Trials and the Cochrane Library, published papers were screened, and data were extracted and analysed. MSC transplantation was associated with significantly improved motor and sensory function in humans, and significantly increased locomotor function in animals. However, there are discrepancies between the studies of human participants and animal models, including timing of MSC transplant post-injury and source of MSCs. Additionally, difficulty in the comparison of functional outcome measures across species limits the predictive nature of the animal research. These findings have been summarised, and recommendations for further research are discussed to better enable the translation of animal models to MSC-based human clinical therapy.
dc.languageen
dc.publisherMDPI
dc.rightsLicence for this article: https://creativecommons.org/licenses/by/4.0/
dc.sourceeissn: 2079-7737
dc.subjectmesenchymal stem cell
dc.subjectspinal cord injury
dc.subjectASIA score
dc.subjectAIS grade
dc.subjectBBB score
dc.subjectfunctional outcome
dc.titleThe Comparative Effects of Mesenchymal Stem Cell Transplantation Therapy for Spinal Cord Injury in Humans and Animal Models: A Systematic Review and Meta-Analysis
dc.typearticle
dc.date.updated2021-03-18T03:07:43Z
dc.date.accepted2021-03-12


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