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    The Comparative Effects of Mesenchymal Stem Cell Transplantation Therapy for Spinal Cord Injury in Humans and Animal Models: A Systematic Review and Meta-Analysis

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    Authors
    Johnson, Louis D. V.; email: louisdvj@gmail.com
    Pickard, Mark R.; email: m.pickard@chester.ac.uk
    Johnson, William E. B.; email: eustace.johnson@chester.ac.uk
    Publication Date
    2021-03-16
    
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    Abstract
    Animal models have been used in preclinical research to examine potential new treatments for spinal cord injury (SCI), including mesenchymal stem cell (MSC) transplantation. MSC transplants have been studied in early human trials. Whether the animal models represent the human studies is unclear. This systematic review and meta-analysis has examined the effects of MSC transplants in human and animal studies. Following searches of PubMed, Clinical Trials and the Cochrane Library, published papers were screened, and data were extracted and analysed. MSC transplantation was associated with significantly improved motor and sensory function in humans, and significantly increased locomotor function in animals. However, there are discrepancies between the studies of human participants and animal models, including timing of MSC transplant post-injury and source of MSCs. Additionally, difficulty in the comparison of functional outcome measures across species limits the predictive nature of the animal research. These findings have been summarised, and recommendations for further research are discussed to better enable the translation of animal models to MSC-based human clinical therapy.
    Citation
    Biology, volume 10, issue 3, page e230
    Publisher
    MDPI
    URI
    http://hdl.handle.net/10034/624358
    Type
    article
    Description
    From MDPI via Jisc Publications Router
    History: accepted 2021-03-12, pub-electronic 2021-03-16
    Publication status: Published
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