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dc.contributor.authorFerreira Soares, Isabela
dc.contributor.authorLópez-Camacho, César
dc.contributor.authorNunes Rodrigues-da-Silva, Rodrigo
dc.contributor.authorda Silva Matos, Ada
dc.contributor.authorde Oliveira Baptista, Barbara
dc.contributor.authorRenato Rivas Totino, Paulo
dc.contributor.authorMedeiros de Souza, Rodrigo
dc.contributor.authorHarrison, Kate
dc.contributor.authorGimenez, Alba Marina
dc.contributor.authorOliveira de Freitas, Elisângela
dc.contributor.authorKim, Young Chan
dc.contributor.authorOliveira-Ferreira, Joseli
dc.contributor.authorDaniel-Ribeiro, Cláudio Tadeu
dc.contributor.authorReyes-Sandoval, Arturo
dc.contributor.authorPratt-Riccio, Lilian Rose
dc.contributor.authorda Costa Lima-Junior, Josué
dc.date.accessioned2020-11-20T13:17:51Z
dc.date.available2020-11-20T13:17:51Z
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/623999/304560_3_merged_1592600049.pdf?sequence=1
dc.identifier.citationSoares, I. F., López-Camacho, C., Rodrigues-da-Silva, R. N., da Silva Matos, A., de Oliveira Baptista, B., Totino, P. R. R., ... & Kim, Y. C. (2020). Recombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazon. Scientific reports, 10(1), 1-14.en_US
dc.identifier.urihttp://hdl.handle.net/10034/623999
dc.description.abstractCircumsporozoite protein (CSP) variants of P. vivax, besides having variations in the protein repetitive portion, can differ from each other in aspects such as geographical distribution, intensity of transmission, vectorial competence and immune response. Such aspects must be considered to P. vivax vaccine development. Therefore, we evaluated the immunogenicity of novel recombinant proteins corresponding to each of the three P. vivax allelic variants (VK210, VK247 and P. vivax-like) and of the C-terminal region (shared by all PvCSP variants) in naturally malaria-exposed populations of Brazilian Amazon. Our results demonstrated that PvCSP-VK210 was the major target of humoral immune response in studied population, presenting higher frequency and magnitude of IgG response. The IgG subclass profile showed a prevalence of cytophilic antibodies (IgG1 and IgG3), that seem to have an essential role in protective immune response. Differently of PvCSP allelic variants, antibodies elicited against C-terminal region of protein did not correlate with epidemiological parameters, bringing additional evidence that humoral response against this protein region is not essential to protective immunity. Taken together, these findings increase the knowledge on serological response to distinct PvCSP allelic variants and may contribute to the development of a global and effective P. vivax vaccine.en_US
dc.publisherNature Researchen_US
dc.relation.urlhttps://www.nature.com/articles/s41598-020-70893-3en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.subjectPlasmodium vivaxen_US
dc.subjectvaccine developmenten_US
dc.subjectnovel recombinant proteinsen_US
dc.subjectantibody recognitionen_US
dc.titleRecombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazonen_US
dc.typeArticleen_US
dc.identifier.eissn2045-2322en_US
dc.contributor.departmentInstituto Oswaldo Cruz; University of Oxford; Instituto de Tecnologia de Imunobiológicos, Fiocruz; ; Universidade Federal do Acre, Rio Branco;en_US
dc.identifier.journalScientific Reportsen_US
or.grant.openaccessYesen_US
rioxxterms.funderCNPq/Papes (Programa de Apoio Pesquisa Estratégica em Saúde), Inovabio grant program (BIO-004-FIO-17-2-11-Bio-Manguinhos/Fiocruz) and Fiocruz (PAEF II, IOC-023-FIO-18-2-47)en_US
rioxxterms.identifier.projectRKT16/01en_US
rioxxterms.versionAMen_US
rioxxterms.versionofrecord10.1038/s41598-020-70893-3en_US
rioxxterms.licenseref.startdate2020-08-20
dcterms.dateAccepted2020-08-03
rioxxterms.publicationdate2020-08-20


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Attribution-NonCommercial-NoDerivatives 4.0 International
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