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dc.contributor.authorMiller, Matthew R.
dc.contributor.authorKruger, Marlena C.
dc.contributor.authorWynne, Chris
dc.contributor.authorWaaka, Devonie
dc.contributor.authorLi, Weili
dc.contributor.authorFrampton, Chris
dc.contributor.authorWolber, Fran M.
dc.contributor.authorEason, Charles
dc.date.accessioned2020-11-11T12:43:36Z
dc.date.available2020-11-11T12:43:36Z
dc.date.issued2018-02-02
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/623951/Accepted%20version%201.pdf?sequence=3
dc.identifier.citationMiller, M. R., Kruger, M. C., Wynne, C., Waaka, D., Li, W., Frampton, C., ... & Eason, C. (2020). Bioavailability of Orally Administered Active Lipid Compounds from Four Different Greenshell™ Mussel Formats. Marine Drugs, 18(11), 524.en_US
dc.identifier.issn0034-6659
dc.identifier.urihttp://hdl.handle.net/10034/623951
dc.description.abstractAbstract: Greenshell™ mussel (GSM, Perna canaliculus) is New Zealand’s most important aquaculture species. They are a good source of long chain-polyunsaturated fatty acids (n-3 LC PUFA). Beyond a traditional food product, GSMs are also sold as mussel powders and oil extract formats in the nutraceutical markets. In this study, a four-sequence, single dose, randomized crossover human trial with eight evaluable healthy male participants was undertaken to determine the bioavailability of the n-3 LC PUFA in four different GSM formats (oil, powder, food ingredient and half-shell unprocessed whole mussel) by measuring area under the curve (AUC) and maximal concentration (CMax). Blood samples were collected at baseline and up to 48 h after initiation of product consumption in each administration period. There were minor differences between the bioavailability of FA (fatty acid) between the different GSM formats. Eicosapentaenoic acid (EPA) peak concentrations and plasma exposures were significantly lower with GSM oil compared to GSM half-shell and GSM powder formats, which resulted in AUC0–48 for the intake of GSM half-shell mussel and GSM powder being significantly higher than that for GSM oil (p = 0.013, f= 4.84). This equated to a 20.6% and 24.3% increase in the amount of EPA present in the plasma after consumption of half-shell mussels and mussel powder respectively compared to GSM oil. GSM oil produced the shortest median time to maximal plasma n-3 LC PUFA concentration of all evaluated products demonstrated by a shorter maximum measured plasma concentration (TMax = 5 h). Docosahexaenoic acid (DHA) and n-3 LC PUFA plasma exposure parameters were statistically comparable across the four GSM products evaluated.en_US
dc.language.isoenen_US
dc.publisherEmerald Publishing Limiteden_US
dc.relation.urlhttps://www.mdpi.com/1660-3397/18/11/524/htmen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjecteicosapentaenoic aciden_US
dc.subjectdocosahexaenoic aciden_US
dc.subjectGreen lipped musselsen_US
dc.subjectPerna canaliculusen_US
dc.subjectpharmacokineticsen_US
dc.titleBioavailability of Orally Administered Active Lipid Compounds from four Different Greenshell™ Mussel Formatsen_US
dc.typeArticleen_US
dc.identifier.eissn1660-3397en_US
dc.contributor.departmentCawthron Institute; Massey University; Christchurch Clinical Studies Trust (CSST); University of Chester; University of Otago;en_US
dc.identifier.journalMarine Drugsen_US
dc.date.accepted2017-09-02
or.grant.openaccessYesen_US
rioxxterms.funderThis research was supported by the New Zealand High Value Nutrition National Science Challenge (Musseling up: High-value Greenshell™ mussel foods; UOAX1421) which provided financial support to conduct the research, authorship, and/or publication of this article.en_US
rioxxterms.identifier.projectIFS16-01en_US
rioxxterms.versionAMen_US
rioxxterms.versionofrecorddoi:10.3390/md18110524en_US
rioxxterms.licenseref.startdate2020-10-23
rioxxterms.publicationdate2020-10-23
dc.dateAccepted2020-10-19
dc.date.deposited11-11-2020en_US


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Attribution-NonCommercial-NoDerivatives 4.0 International
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