Bioavailability of Orally Administered Active Lipid Compounds from four Different Greenshell™ Mussel Formats
Authors
Miller, Matthew R.Kruger, Marlena C.
Wynne, Chris
Waaka, Devonie
Li, Weili
Frampton, Chris
Wolber, Fran M.
Eason, Charles
Affiliation
Cawthron Institute; Massey University; Christchurch Clinical Studies Trust (CSST); University of Chester; University of Otago;Publication Date
2018-02-02
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Abstract: Greenshell™ mussel (GSM, Perna canaliculus) is New Zealand’s most important aquaculture species. They are a good source of long chain-polyunsaturated fatty acids (n-3 LC PUFA). Beyond a traditional food product, GSMs are also sold as mussel powders and oil extract formats in the nutraceutical markets. In this study, a four-sequence, single dose, randomized crossover human trial with eight evaluable healthy male participants was undertaken to determine the bioavailability of the n-3 LC PUFA in four different GSM formats (oil, powder, food ingredient and half-shell unprocessed whole mussel) by measuring area under the curve (AUC) and maximal concentration (CMax). Blood samples were collected at baseline and up to 48 h after initiation of product consumption in each administration period. There were minor differences between the bioavailability of FA (fatty acid) between the different GSM formats. Eicosapentaenoic acid (EPA) peak concentrations and plasma exposures were significantly lower with GSM oil compared to GSM half-shell and GSM powder formats, which resulted in AUC0–48 for the intake of GSM half-shell mussel and GSM powder being significantly higher than that for GSM oil (p = 0.013, f= 4.84). This equated to a 20.6% and 24.3% increase in the amount of EPA present in the plasma after consumption of half-shell mussels and mussel powder respectively compared to GSM oil. GSM oil produced the shortest median time to maximal plasma n-3 LC PUFA concentration of all evaluated products demonstrated by a shorter maximum measured plasma concentration (TMax = 5 h). Docosahexaenoic acid (DHA) and n-3 LC PUFA plasma exposure parameters were statistically comparable across the four GSM products evaluated.Citation
Miller, M. R., Kruger, M. C., Wynne, C., Waaka, D., Li, W., Frampton, C., ... & Eason, C. (2020). Bioavailability of Orally Administered Active Lipid Compounds from Four Different Greenshell™ Mussel Formats. Marine Drugs, 18(11), 524. https://doi.org/10.3390/md18110524Publisher
MDPIJournal
Marine DrugsAdditional Links
https://www.mdpi.com/1660-3397/18/11/524/htmType
ArticleLanguage
enISSN
0034-6659EISSN
1660-3397ae974a485f413a2113503eed53cd6c53
10.3390/md18110524
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