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dc.contributor.authorIsgin-Atici, Kubra
dc.contributor.authorAlsulami, Sooad
dc.contributor.authorTuran-Demirci, Busra
dc.contributor.authorSurendran, Shelini
dc.contributor.authorSendur, Suleyman Nahit
dc.contributor.authorLay5, Incilay
dc.contributor.authorKarabulut, Erdem
dc.contributor.authorEllahi, Basma
dc.contributor.authorLovegrove, Julie
dc.contributor.authorAlikasifoglu, Mehmet
dc.contributor.authorErbas, Tomris
dc.contributor.authorSanthanakrishnan, Vimaleswaran Karani
dc.contributor.authorBuyuktuncer, Zehra
dc.date.accessioned2020-08-07T14:26:30Z
dc.date.available2020-08-07T14:26:30Z
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/623583/Ellahi%2c%20B.%20Combined%20files.pdf?sequence=10
dc.identifier.citationIsgin-Atici, K., Alsulami, S., Turan-Demirci, B., Surendran, S., Sendur, S. N., Lay, I., . . . Buyuktuncer, Z. (2020). FTO gene–lifestyle interactions on serum adiponectin concentrations and central obesity in a turkish population. International Journal of Food Sciences and Nutrition, 1-11. doi:10.1080/09637486.2020.1802580en_US
dc.identifier.urihttp://hdl.handle.net/10034/623583
dc.descriptionThis is an Accepted Manuscript of an article published by Taylor & Francis International Journal of Food Sciences and Nutrition on 4-8-2020, available online: https://doi.org/10.1080/09637486.2020.1802580en_US
dc.description.abstractThe aim of the study was to investigate whether lifestyle factors modify the association fat mass and obesity-associated (FTO) gene single nucleotide polymorphisms (SNPs) and obesity in a Turkish population. The study included 400 unrelated individuals, aged 24-50 years recruited in a hospital setting. Dietary intake and physical activity were assessed using 24-hour dietary recall and self-report questionnaire, respectively. A genetic risk score (GRS) was developed using FTO SNPs, rs9939609 and rs10163409. Body mass index and fat mass index were significantly associated with FTO SNP rs9939609 (P=0.001 and P=0.002, respectively) and GRS (P=0.002 and P=0.003, respectively). The interactions between SNP rs9939609 and physical activity on adiponectin concentrations, and SNP rs10163409 and dietary protein intake on increased waist circumference were statistically significant (Pinteraction=0.027 and Pinteraction=0.044, respectively). This study demonstrated that the association between FTO SNPs and central obesity might be modified by lifestyle factors in this Turkish population.en_US
dc.publisherTaylor & Francisen_US
dc.relation.urlhttps://www.tandfonline.com/doi/full/10.1080/09637486.2020.1802580en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.subjectFTO gene varianten_US
dc.subjectobesity;en_US
dc.subjectgene-diet interaction;en_US
dc.subjectadiponectin;en_US
dc.subjectphysical activityen_US
dc.subjectgenetic risk score;en_US
dc.titleFTO gene-lifestyle interactions on serum adiponectin concentrations and central obesity in a Turkish populationen_US
dc.typeArticleen_US
dc.identifier.eissn1465-3478en_US
dc.contributor.departmentDepartment of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe University, Ankara, Turkey Department of Food and Nutritional Sciences, University of Reading, PO Box 226, Whiteknights, Reading RG6 6AP, UK: Department of Clinical Nutrition, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia: Department of Endocrinology and Metabolism, School of Medicine, Hacettepe University, Ankara, Turkey: Department of Medical Biochemistry, Faculty of Medicine, Hacettepe University, Ankara, Turkey; Clinical Pathology Laboratory, Hacettepe University Hospitals, Ankara, Turkey: Department of Biostatistics, Faculty of Medicine; Department of Bioinformatics Hacettepe University, Ankara, Turkey: Faculty of Health and Social Care, University of Chester, Chester CH1 4DS, UK: Department of Medical Genetics, School of Medicine, Hacettepe University Ankara, Turkey; Genetics Diagnostic Centre, DAMAGEN, Ankara, Turkeyen_US
dc.identifier.journalInternational Journal of Food Sciences and Nutritionen_US
or.grant.openaccessYesen_US
rioxxterms.funderexternally funded by Saudi Government and Tibutak (Turkey)en_US
rioxxterms.identifier.projectnoneen_US
rioxxterms.versionAMen_US
rioxxterms.versionofrecord10.1080/09637486.2020.1802580en_US
rioxxterms.licenseref.startdate2021-08-04
rioxxterms.publicationdate2020-08-04
dc.dateAccepted2020-07-23
dc.date.deposited2020-08-07en_US
dc.indentifier.issn0963-7486en_US


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