Interaction between Metabolic Genetic Risk Score and Dietary Fatty Acid Intake on Central Obesity in a Ghanaian Population
Authors
Alsulami, SooadNyakotey, David
Dudek, Kamila
Bawah, Abdul-Malik
Lovegrove, Julie A.
Annan, Reggie
Ellahi, Basma
Karani, Santhanakrishnan Vimaleswaran
Affiliation
University of Reading, University of Chester and Kumasi UniversityPublication Date
2020-07-27
Metadata
Show full item recordAbstract
Obesity is a multifactorial condition arising from the interaction between genetic and lifestyle factors. We aimed to assess the impact of lifestyle and genetic factors on obesity-related traits in 302 healthy Ghanaian adults. Dietary intake and physical activity were assessed using a 3 day repeated 24 h dietary recall and global physical activity questionnaire, respectively. Twelve single nucleotide polymorphisms (SNPs) were used to construct 4-SNP, 8-SNP and 12-SNP genetic risk scores (GRSs). The 4-SNP GRS showed significant interactions with dietary fat intakes on waist circumference (WC) (Total fat, Pinteraction = 0.01; saturated fatty acids (SFA), Pinteraction = 0.02; polyunsaturated fatty acids (PUFA), Pinteraction = 0.01 and monounsaturated fatty acids (MUFA), Pinteraction = 0.01). Among individuals with higher intakes of total fat (>47 g/d), SFA (>14 g/d), PUFA (>16 g/d) and MUFA (>16 g/d), individuals with ≥3 risk alleles had a significantly higher WC compared to those with <3 risk alleles. This is the first study of its kind in this population, suggesting that a higher consumption of dietary fatty acid may have the potential to increase the genetic susceptibility of becoming centrally obese. These results support the general dietary recommendations to decrease the intakes of total fat and SFA, to reduce the risk of obesity, particularly in individuals with a higher genetic predisposition to central obesity.Citation
Alsulami, S., Nyakotey, D, A., Dudek, K., Bawah, A., Lovegrove, J, A., Annan, R, A., Ellahi, B. & Vimaleswaran, K. S. (2020). Interaction between Metabolic Genetic Risk Score and Dietary Fatty Acid Intake on Central Obesity in a Ghanaian Population. Nutrients, 12(7), 1906.Publisher
MDPIJournal
NutrientsType
ArticleEISSN
2072-6643ae974a485f413a2113503eed53cd6c53
10.3390/nu12071906
Scopus Count
Collections
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NoDerivatives 4.0 International