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dc.contributor.authorBegum, Saima
dc.contributor.authorJohnson, William Eustace Basil
dc.contributor.authorWorthington, Tony
dc.contributor.authorMartin, Richard
dc.date.accessioned2020-06-26T09:33:57Z
dc.date.available2020-06-26T09:33:57Z
dc.date.issued2016-02-02
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/623521/Begum%202016.pdf?sequence=1
dc.identifier.citationBegum, S., Johnson, W. E., Worthington, T., & Martin, R. A. (2016). The influence of pH and fluid dynamics on the antibacterial efficacy of 45S5 Bioglass. Biomedical Materials, 11(1), 015006.en_US
dc.identifier.doi10.1088/1748-6041/11/1/015006
dc.identifier.urihttp://hdl.handle.net/10034/623521
dc.descriptionThis is an author-created, un-copyedited version of an article accepted for publication/published in Biomedical Materials. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.1088/1748-6041/11/1/015006en_US
dc.description.abstractIn recent years, there has been considerable interest in the potential antibacterial properties that bioactive glasses may possess. However, there have been several conflicting reports on the antibacterial efficacy of 45S5 Bioglass®. Various mechanisms regarding its mode of action have been proposed, such as changes in the environmental pH, increased osmotic pressure, and 'needle-like' sharp glass debris which could potentially damage prokaryotic cell walls and thus inactivate bacteria. In this current study, a systematic investigation was undertaken on the antibacterial efficacy of 45S5 Bioglass® on Escherichia coli NCTC 10538 and Staphylococcus aureus ATCO 6538 under a range of clinically relevant scenarios including varying Bioglass® concentration, direct and indirect contact between Bioglass® and microorganisms, static and shaking incubation conditions, elevated and neutralised pH environments. The results demonstrated that, under elevated pH conditions, Bioglass® particles have no antibacterial effect on S. aureus while a concentration dependent antibacterial effect against E. coli was observed. However, the antibacterial activity ceased when the pH of the media was neutralised. The results of this current study, therefore, suggest that the mechanism of antibacterial activity of Bioglass® is associated with changes in the environmental pH; an environment that is less likely to occur in vivo due to buffering of the system.en_US
dc.publisherIOP Publishingen_US
dc.relation.urlhttps://iopscience.iop.org/article/10.1088/1748-6041/11/1/015006/pdfen_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.subjectBone repairen_US
dc.subjectBioglassen_US
dc.subjectAntimicrobialen_US
dc.titleThe influence of pH and fluid dynamics on the antibacterial efficacy of 45S5 Bioglass Short title: Antibacterial efficacy of 45S5 Bioglassen_US
dc.typeArticleen_US
dc.identifier.eissn1748-605Xen_US
dc.contributor.departmentAston Universityen_US
dc.identifier.journalBiomedical Materialsen_US
or.grant.openaccessYesen_US
rioxxterms.funderThe authors would like to thank the Aston Research Centre for Healthy Ageing for funding this research.en_US
rioxxterms.identifier.projectUnfundeden_US
rioxxterms.versionAMen_US
rioxxterms.versionofrecordhttp://dx.doi.org/10.1088/1748-6041/11/1/015006en_US
rioxxterms.licenseref.startdate2017-02-02
refterms.dateFCD2020-06-25T10:50:46Z
refterms.versionFCDAM
refterms.dateFOA2020-06-26T09:33:58Z
rioxxterms.publicationdate2016-02-02
dc.dateAccepted2016-01-07
dc.date.deposited2020-06-26en_US
dc.indentifier.issn1748-6041en_US


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