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dc.contributor.authorSurendran, S
dc.contributor.authorAlsulami, S
dc.contributor.authorLankeshwara, R
dc.contributor.authorJayawardena, R
dc.contributor.authorWetthasinghe, K
dc.contributor.authorSarkar, S
dc.contributor.authorEllahi, B
dc.contributor.authorLovegrove, JA
dc.contributor.authorAnthony, D
dc.contributor.authorVimaleswaran, KS
dc.date.accessioned2020-06-11T08:19:22Z
dc.date.available2020-06-11T08:19:22Z
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/623488/Surendran%20et%20al_main%20text_Unmarked.pdf?sequence=4
dc.identifier.citationSurendran, S., Alsulami, S., Lankeshwara, R., Jayawardena, R., Wetthasinghe, K., Sarkar, S., ... & Vimaleswaran, K. S. (2019). A genetic approach to examine the relationship between vitamin B 12 status and metabolic traits in a South Asian population. International Journal of Diabetes in Developing Countries, 40, 21–31.en_US
dc.identifier.doi10.1007/s13410-019-00749-8
dc.identifier.urihttp://hdl.handle.net/10034/623488
dc.description.abstractBackground: Observational studies in South Asian populations have suggested an association between vitamin B12 status and metabolic traits; however, the findings have been inconclusive. Hence, the aim of the present study was to use a genetic approach to explore the relationship between metabolic traits and vitamin B12 status in a Sri Lankan population and to investigate whether these relationships were modified by dietary intake. Methods: A total of 109 Sinhalese adults (61 men and 48 women aged 25-50 years), from Colombo city underwent anthropometric, biochemical, dietary intake analysis and genetic tests. Genetic risk scores (GRS) based on 10 metabolic single nucleotide polymorphisms (SNPs) (metabolic-GRS) and 10 vitamin B12 SNPs (B12-GRS) were constructed. Results: The B12-GRS was significantly associated with serum vitamin B12 (P=0.008), but not with metabolic traits (P>0.05); whereas, the metabolic-GRS had no effect on metabolic traits (P>0.05) and vitamin B12 concentrations (P>0.05). An interaction was observed between B12-GRS and protein energy intake (%) on waist circumference (P=0.002). Interactions were also seen between the metabolic-GRS and carbohydrate energy intake (%) on waist to hip ratio (P=0.015). Conclusion: Our findings suggest that a genetically lowered vitamin B12 concentration may have an impact on central obesity in the presence of a dietary influence; however, our study failed to provide evidence for an impact of metabolic-GRS on lowering B12 concentrations. Given that our study has a small sample size, further large studies are required to confirm our findings.en_US
dc.publisherSpringer Indiaen_US
dc.relation.urlhttps://link.springer.com/article/10.1007/s13410-019-00749-8#article-infoen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.subjectSNPen_US
dc.subjectBody mass indexen_US
dc.subjectObesityen_US
dc.subjectMetabolic traitsen_US
dc.subjectVitamin B12 pathwayen_US
dc.subjectSinhaleseen_US
dc.subjectSri Lankaen_US
dc.subjectNutrigeneticsen_US
dc.titleA genetic approach to examine the relationship between vitamin B12 status and metabolic traits in a South Asian populationen_US
dc.typeArticleen_US
dc.identifier.eissn1998-3832en_US
dc.contributor.departmentUniversity of Reading; University of Colombo; University of Technology Brisbane; University of Bournemouth; University of Chesteren_US
dc.identifier.journalInternational Journal of Diabetes in Developing Countriesen_US
or.grant.openaccessYesen_US
rioxxterms.fundernoneen_US
rioxxterms.identifier.projectnoneen_US
rioxxterms.versionAMen_US
rioxxterms.versionofrecordhttps://doi.org/10.1007/s13410-019-00749-8en_US
rioxxterms.licenseref.startdate2019-05-25
refterms.dateFCD2020-06-10T16:38:16Z
refterms.versionFCDAM
refterms.dateFOA2019-05-27T00:00:00Z
rioxxterms.publicationdate2019-05-27
dc.dateAccepted2019-05-02
dc.date.deposited2020-06-11en_US
dc.indentifier.issn0973-3930en_US


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