A genetic approach to examine the relationship between vitamin B12 status and metabolic traits in a South Asian population
dc.contributor.author | Surendran, Shelini | |
dc.contributor.author | Alsulami, Sooad | |
dc.contributor.author | Lankeshwara, R. | |
dc.contributor.author | Jayawardena, Ranil | |
dc.contributor.author | Wetthasinghe, Kalum | |
dc.contributor.author | Sarkar, Swrajit | |
dc.contributor.author | Ellahi, Basma | |
dc.contributor.author | Lovegrove, Julie A. | |
dc.contributor.author | Anthony, Dimonge J. | |
dc.contributor.author | Vimaleswaran, Karani S. | |
dc.date.accessioned | 2020-06-11T08:19:22Z | |
dc.date.available | 2020-06-11T08:19:22Z | |
dc.date.issued | 2019-05-27 | |
dc.identifier | https://chesterrep.openrepository.com/bitstream/handle/10034/623488/Surendran%20et%20al_main%20text_Unmarked.pdf?sequence=4 | |
dc.identifier.citation | Surendran, S., Alsulami, S., Lankeshwara, R., Jayawardena, R., Wetthasinghe, K., Sarkar, S., ... & Vimaleswaran, K. S. (2019). A genetic approach to examine the relationship between vitamin B 12 status and metabolic traits in a South Asian population. International Journal of Diabetes in Developing Countries, 40, 21–31. https://doi.org/10.1007/s13410-019-00749-8 | en_US |
dc.identifier.issn | 0973-3930 | |
dc.identifier.doi | 10.1007/s13410-019-00749-8 | |
dc.identifier.uri | http://hdl.handle.net/10034/623488 | |
dc.description.abstract | Background: Observational studies in South Asian populations have suggested an association between vitamin B12 status and metabolic traits; however, the findings have been inconclusive. Hence, the aim of the present study was to use a genetic approach to explore the relationship between metabolic traits and vitamin B12 status in a Sri Lankan population and to investigate whether these relationships were modified by dietary intake. Methods: A total of 109 Sinhalese adults (61 men and 48 women aged 25-50 years), from Colombo city underwent anthropometric, biochemical, dietary intake analysis and genetic tests. Genetic risk scores (GRS) based on 10 metabolic single nucleotide polymorphisms (SNPs) (metabolic-GRS) and 10 vitamin B12 SNPs (B12-GRS) were constructed. Results: The B12-GRS was significantly associated with serum vitamin B12 (P=0.008), but not with metabolic traits (P>0.05); whereas, the metabolic-GRS had no effect on metabolic traits (P>0.05) and vitamin B12 concentrations (P>0.05). An interaction was observed between B12-GRS and protein energy intake (%) on waist circumference (P=0.002). Interactions were also seen between the metabolic-GRS and carbohydrate energy intake (%) on waist to hip ratio (P=0.015). Conclusion: Our findings suggest that a genetically lowered vitamin B12 concentration may have an impact on central obesity in the presence of a dietary influence; however, our study failed to provide evidence for an impact of metabolic-GRS on lowering B12 concentrations. Given that our study has a small sample size, further large studies are required to confirm our findings. | en_US |
dc.publisher | Springer | en_US |
dc.relation.url | https://link.springer.com/article/10.1007/s13410-019-00749-8 | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
dc.subject | SNP | en_US |
dc.subject | Body mass index | en_US |
dc.subject | Obesity | en_US |
dc.subject | Metabolic traits | en_US |
dc.subject | Vitamin B12 pathway | en_US |
dc.subject | Sinhalese | en_US |
dc.subject | Sri Lanka | en_US |
dc.subject | Nutrigenetics | en_US |
dc.title | A genetic approach to examine the relationship between vitamin B12 status and metabolic traits in a South Asian population | en_US |
dc.type | Article | en_US |
dc.identifier.eissn | 1998-3832 | en_US |
dc.contributor.department | University of Reading; University of Colombo; University of Technology Brisbane; University of Bournemouth; University of Chester | en_US |
dc.identifier.journal | International Journal of Diabetes in Developing Countries | en_US |
or.grant.openaccess | Yes | en_US |
rioxxterms.funder | none | en_US |
rioxxterms.identifier.project | none | en_US |
rioxxterms.version | AM | en_US |
rioxxterms.versionofrecord | https://doi.org/10.1007/s13410-019-00749-8 | en_US |
rioxxterms.licenseref.startdate | 2019-05-25 | |
rioxxterms.publicationdate | 2019-05-27 | |
dc.dateAccepted | 2019-05-02 | |
dc.date.deposited | 2020-06-11 | en_US |