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dc.contributor.authorMartins, Daniel
dc.contributor.authorLeslie, Monica
dc.contributor.authorRodan, Sarah
dc.contributor.authorZelaya, Fernando
dc.contributor.authorTreasure, Janet
dc.contributor.authorPaloyelis, Yannis
dc.identifier.citationDaniel, M., Leslie, M., Rodan, S., Zelaya, F., Treasure, J. & Paloyelis, Y. (2020 - forthcoming). Investigating resting brain perfusion abnormalities and disease target-engagement by intranasal oxytocin in women with bulimia nervosa and binge-eating disorder and healthy controls. Translational Psychiaty, 10, 180.en_US
dc.description.abstractAdvances in the treatment of bulimia nervosa and binge eating disorder (BN/BED) have been marred by our limited understanding of the underpinning neurobiology. Here we measured regional cerebral blood flow (rCBF) to map resting perfusion abnormalities in women with BN/BED compared to healthy controls and investigate if intranasal oxytocin (OT), proposed as a potential treatment, can restore perfusion in disorder-related brain circuits. Twenty-four women with BN/BED and 23 healthy women participated in a randomised, double-blind, crossover, placebo-controlled study. We used arterial spin labelling MRI to measure rCBF and the effects of an acute dose of intranasal OT (40IU) or placebo over 18-26 minutes post-dosing, as we have previously shown robust OT-induced changes in resting rCBF in men in a similar time-window (15-36 min post-dosing). We tested for effects of treatment, diagnosis and their interaction on extracted rCBF values in anatomical regions-of-interest previously implicated in BN/BED by other neuroimaging modalities, and conducted exploratory whole-brain analyses to investigate previously unidentified brain regions. We demonstrated that women with BN/BED presented increased resting rCBF in the medial prefrontal and orbitofrontal cortices, anterior cingulate gyrus, posterior insula and middle/inferior temporal gyri bilaterally. Hyperperfusion in these areas specifically correlated with eating symptoms severity in patients. Our data did not support a normalizing effect of intranasal OT on perfusion abnormalities in these patients, at least for the specific dose (40 IU) and post-dosing interval (18-26 minutes) examined. Our findings enhance our understanding of resting brain abnormalities in BN/BED and identify resting rCBF as a non-invasive potential biomarker for disease-related changes and treatment monitoring. They also highlight the need for a comprehensive investigation of intranasal OT pharmacodynamics in women before we can fully ascertain its therapeutic value in disorders affecting predominantly this gender, such as BN/BED.en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.titleInvestigating resting brain perfusion abnormalities and disease target-engagement by intranasal oxytocin in women with bulimia nervosa and binge-eating disorder and healthy controlsen_US
dc.title.alternativeBrain perfusion alterations in bulimia/binge-eatingen_US
dc.contributor.departmentKing's College London; University College Londonen_US
dc.identifier.journalTranslational Psychiatryen_US
rioxxterms.funderThe Swiss Fund for Anorexia Nervosa; The Guy's and St Thomas' Foundation Trust; the King's Health Partners Challenge Fund; the Economic and Social Research Council; the National Institute for Health Research (NIHR) Mental Health Biomedical Research Centreen_US
rioxxterms.identifier.projectNot applicableen_US

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Attribution-NonCommercial-NoDerivatives 4.0 International
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