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dc.contributor.authorDallaway, Alexander
dc.contributor.authorKite, Chris
dc.contributor.authorGriffin, Corbyn
dc.contributor.authorDuncan, Michael
dc.contributor.authorTallis, J.
dc.contributor.authorRenshaw, D.
dc.contributor.authorHattersley, John
dc.date.accessioned2020-04-16T13:26:48Z
dc.date.available2020-04-16T13:26:48Z
dc.identifier.citationDallaway, A., Kite, C., Griffen, C., Duncan, M., Tallis, J., Renshaw, D., & Hattersley, J. (2020). Age-related degeneration of the lumbar paravertebral muscles: Systematic review and three-level meta-regression. Experimental Gerontology, 110856.en_US
dc.identifier.urihttp://hdl.handle.net/10034/623354
dc.descriptionFirst meta-analysis showing age-related low back muscle degeneration in older adults Disparate methodologies explain a large proportion of variance between studies. Lumbar muscle degeneration is sex, muscle and lumbar level-specific. High resolution imaging modalities are recommended for quantitative analysis.en_US
dc.description.abstractBackground Morphological changes of the lumbar spine muscles are not well characterised with ageing. To further the understanding of age-related degeneration of the lumbar spine musculature, normative morphological changes that occur within the paravertebral muscles must first be established. Methods A systematic review and meta-regressions were conducted adhering to PRISMA guidelines. Searches for published and unpublished data were completed in June 2019. Results Searches returned 4781 articles. 34 articles were included in the quantitative analysis. Three-level meta-analyses showed age-related atrophy (r = −0.26; 95% CI: −0.33, −0.17) and fat infiltration (r = 0.39; 95% CI: 0.28, 0.50) in the lumbar paravertebral muscles. Degenerative changes were muscle-specific and men (r = −0.32; 95% CI: −0.61, 0.01) exhibited significantly greater muscle atrophy than women (r = −0.24; 95% CI: −0.47, 0.03). Imaging modality, specifically ultrasound, also influenced age-related muscle atrophy. Measurements taken across all lumbar levels revealed the greatest fat infiltration with ageing (r = 0.58, 95% CI: 0.35, 0.74). Moderators explained a large proportion of between-study variance in true effects for muscle atrophy (72.6%) and fat infiltration (79.8%) models. Conclusions Lumbar paravertebral muscles undergo age-related degeneration in healthy adults with muscle, lumbar level and sex-specific responses. Future studies should use high-resolution imaging modalities to quantify muscle atrophy and fat infiltration.en_US
dc.publisherElsevieren_US
dc.relation.urlhttps://www.sciencedirect.com/science/article/abs/pii/S0531556519308538en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.subjectBack musclesen_US
dc.subjectLumbosacral regionen_US
dc.subjectSarcopeniaen_US
dc.subjectMuscle degenerationen_US
dc.subjectHealthy ageingen_US
dc.titleAge-related degeneration of the lumbar paravertebral muscles: Systematic review and three-level meta-regressionen_US
dc.typeArticleen_US
dc.identifier.eissn1873-6815en_US
dc.contributor.departmentCoventry University, University Hospitals Coventry and Warwickshire, Aston University, University of Chesteren_US
dc.identifier.journalExperimental Gerontologyen_US
or.grant.openaccessNoen_US
rioxxterms.funderUniversity of Coventry and University Hospitals Coventry and warwickshireen_US
rioxxterms.identifier.projectRKT16/01en_US
rioxxterms.versionAOen_US
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.exger.2020.110856en_US
rioxxterms.licenseref.startdate2021-01-30
rioxxterms.publicationdate2020-01-30
dc.dateAccepted2020-01-28
dc.date.deposited2020-04-16en_US
dc.indentifier.issn0531-5565en_US


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