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dc.contributor.authorPugh, Jamie
dc.contributor.authorSage, Stephen
dc.contributor.authorHutson, Mark
dc.contributor.authorDoran, Dominic
dc.contributor.authorFleming, Simon
dc.contributor.authorHighton, Jamie M.
dc.contributor.authorMorton, James
dc.contributor.authorClose, Graeme
dc.date.accessioned2020-01-13T14:32:01Z
dc.date.available2020-01-13T14:32:01Z
dc.date.issued2017-10-20
dc.identifier.citationPugh, J. N., Sage, S., Hutson, M., Doran, D. A., Fleming, S. C., Highton, J., . . . Close, G. L. (2017). Glutamine supplementation reduces markers of intestinal permeability during running in the heat in a dose-dependent manner. European Journal of Applied Physiology, 117(12), 2569-2577. doi:10.1007/s00421-017-3744-4en_US
dc.identifier.doi10.1007/s00421-017-3744-4
dc.identifier.urihttp://hdl.handle.net/10034/623065
dc.description.abstractPurpose To examine the dose–response effects of acute glutamine supplementation on markers of gastrointestinal (GI) permeability, damage and, secondary, subjective symptoms of GI discomfort in response to running in the heat. Methods Ten recreationally active males completed a total of four exercise trials; a placebo trial and three glutamine trials at 0.25, 0.5 and 0.9 g kg−1 of fat-free mass (FFM) consumed 2 h before exercise. Each exercise trial consisted of a 60-min treadmill run at 70% of ̇VO2max in an environmental chamber set at 30 °C. GI permeability was measured using ratio of lactulose to rhamnose (L:R) in serum. Plasma glutamine and intestinal fatty acid binding protein (I-FABP) concentrations were determined pre and post exercise. Subjective GI symptoms were assessed 45 min and 24 h post-exercise. Results Relative to placebo, L:R was likely lower following 0.25 g kg−1 (mean difference: − 0.023; ± 0.021) and 0.5 g kg−1 (− 0.019; ± 0.019) and very likely following 0.9 g kg− 1 (− 0.034; ± 0.024). GI symptoms were typically low and there was no effect of supplementation. Discussion Acute oral glutamine consumption attenuates GI permeability relative to placebo even at lower doses of 0.25 g kg−1, although larger doses may be more effective. It remains unclear if this will lead to reductions in GI symptoms. Athletes competing in the heat may, therefore, benefit from acute glutamine supplementation prior to exercise in order to maintain gastrointestinal integrity.en_US
dc.publisherSpringeren_US
dc.relation.urlhttps://link.springer.com/article/10.1007/s00421-017-3744-4en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleGlutamine supplementation reduces markers of intestinal permeability during running in the heat in a dose-dependent manneren_US
dc.typeArticleen_US
dc.identifier.eissn1439-6327en_US
dc.identifier.journalEuropean Journal of Applied Physiologyen_US
or.grant.openaccessYesen_US
rioxxterms.funderUnfundeden_US
rioxxterms.identifier.projectUnfundeden_US
rioxxterms.versionVoRen_US
rioxxterms.versionofrecordhttps://doi.org/10.1007/s00421-017-3744-4en_US
rioxxterms.licenseref.startdate2017-10-20
refterms.dateFCD2020-01-09T08:57:01Z
refterms.versionFCDAM
refterms.dateFOA2020-01-09T00:00:00Z
rioxxterms.publicationdate2017-10-20
dc.dateAccepted2017-10-08
dc.date.deposited2020-01-13en_US
dc.indentifier.issn1439-6319en_US


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