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dc.contributor.authorHalevas, Eleftherios
dc.contributor.authorMavroidi, Barbara
dc.contributor.authorMoschona, Alexandra
dc.contributor.authorHadjispyrou, Spyros
dc.contributor.authorSalifoglou, Athanasios
dc.contributor.authorPelecanou, Maria
dc.contributor.authorLitsardakis, George
dc.contributor.authorPantazaki, Anastasia
dc.contributor.authorSwanson, Claudia H.
dc.contributor.authorSmith, Graham C.
dc.date.accessioned2019-10-02T11:52:30Z
dc.date.available2019-10-02T11:52:30Z
dc.date.issued2019-07-15
dc.identifier.citationHalevas, E., Mavroidi, B., Swanson, C.H., Smith, G.C., Moschona, A., Hadjispyrou, S., ... Litsardakis, G. (2019). Magnetic cationic liposomal nanocarriers for the efficient drug delivery of a curcumin-based vanadium complex with anticancer potential. Journal of Inorganic Biochemistry, 199, 110778. https://doi.org/10.1016/j.jinorgbio.2019.110778en_US
dc.identifier.issn0162-0134
dc.identifier.doi10.1016/jinorgbio.2019.110778
dc.identifier.urihttp://hdl.handle.net/10034/622664
dc.description.abstractIn this work novel magnetic cationic liposomal nanoformulations were synthesized for the encapsulation of a crystallographically defined ternary V(IV)-curcumin-bipyridine (VCur) complex with proven bioactivity, as potential anticancer agents. The liposomal vesicles were produced via the thin film hydration method employing N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium (DOTAP) and egg phosphatidylcholine lipids and were magnetized through the addition of citric acid surface-modified monodispersed magnetite colloidal magnetic nanoparticles. The obtained nanoformulations were evaluated for their structural and textural properties and shown to have exceptional stability and enhanced solubility in physiological media, demonstrated by the entrapment efficiency and loading capacity results and the in vitro release studies of their cargo. Furthermore, the generated liposomal formulations preserved the superparamagnetic behavior of the employed magnetic core maintaining the physicochemical and morphological requirements for targeted drug delivery applications. The novel nanomaterials were further biologically evaluated for their DNA interaction potential and were found to act as intercalators. The findings suggest that the positively charged magnetic liposomal nanoformulations can generate increased concentration of their cargo at the DNA site, offering a further dimension in the importance of cationic liposomes as nanocarriers of hydrophobic anticancer metal ion complexes for the development of new multifunctional pharmaceutical nanomaterials with enhanced bioavailability and targeted antitumor activity.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.urlhttps://www.sciencedirect.com/science/article/pii/S0162013419302910?via%3Dihuben_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.subjectVanadium-circumin complexesen_US
dc.subjectmagnetic cationic liposomesen_US
dc.subjectdrug encapsulationen_US
dc.subjecttargeted drug deliveryen_US
dc.subjectDNA interactionen_US
dc.subjectanticancer potentialen_US
dc.titleMagnetic cationic liposomal nanocarriers for the efficient drug delivery of a curcumin-based vanadium complex with anticancer potentialen_US
dc.typeArticleen_US
dc.identifier.eissn1873-3344
dc.contributor.departmentUniversity of Chester; Aristotle University; Demokritos Centre for Scientific Research, Athensen_US
dc.identifier.journalJournal of Inorganic Biochemistryen_US
or.grant.openaccessYesen_US
rioxxterms.funderunfundeden_US
rioxxterms.identifier.projectunfundeden_US
rioxxterms.versionAMen_US
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.jinorgbio.2019.110778en_US
rioxxterms.licenseref.startdate2020-07-15
rioxxterms.publicationdate2019-07-15
dc.dateAccepted2019-07-14
dc.date.deposited2019-10-02


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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International