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dc.contributor.authorHalevas, Eleftherios; email: lefterishalevas@gmail.com
dc.contributor.authorMavroidi, Barbara
dc.contributor.authorSwanson, Claudia H
dc.contributor.authorSmith, Graham C
dc.contributor.authorMoschona, Alexandra
dc.contributor.authorHadjispyrou, Spyros
dc.contributor.authorSalifoglou, Athanasios
dc.contributor.authorPantazaki, Anastasia A
dc.contributor.authorPelecanou, Maria
dc.contributor.authorLitsardakis, George
dc.date.accessioned2019-09-06T01:07:00Z
dc.date.available2019-09-06T01:07:00Z
dc.date.issued2019-07-15
dc.date.submitted2019-05-10
dc.identifierpubmed: 31442839
dc.identifierpii: S0162-0134(19)30291-0
dc.identifierdoi: 10.1016/j.jinorgbio.2019.110778
dc.identifier.citationJournal of inorganic biochemistry, volume 199, page 110778
dc.identifier.urihttp://hdl.handle.net/10034/622563
dc.descriptionFrom PubMed via Jisc Publications Router
dc.descriptionHistory: received 2019-05-10, revised 2019-07-12, accepted 2019-07-14
dc.descriptionPublication status: aheadofprint
dc.description.abstractIn this work novel magnetic cationic liposomal nanoformulations were synthesized for the encapsulation of a crystallographically defined ternary V(IV)-curcumin-bipyridine (VCur) complex with proven bioactivity, as potential anticancer agents. The liposomal vesicles were produced via the thin film hydration method employing N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium (DOTAP) and egg phosphatidylcholine lipids and were magnetized through the addition of citric acid surface-modified monodispersed magnetite colloidal magnetic nanoparticles. The obtained nanoformulations were evaluated for their structural and textural properties and shown to have exceptional stability and enhanced solubility in physiological media, demonstrated by the entrapment efficiency and loading capacity results and the in vitro release studies of their cargo. Furthermore, the generated liposomal formulations preserved the superparamagnetic behavior of the employed magnetic core maintaining the physicochemical and morphological requirements for targeted drug delivery applications. The novel nanomaterials were further biologically evaluated for their DNA interaction potential and were found to act as intercalators. The findings suggest that the positively charged magnetic liposomal nanoformulations can generate increased concentration of their cargo at the DNA site, offering a further dimension in the importance of cationic liposomes as nanocarriers of hydrophobic anticancer metal ion complexes for the development of new multifunctional pharmaceutical nanomaterials with enhanced bioavailability and targeted antitumor activity. [Abstract copyright: Copyright © 2019 Elsevier Inc. All rights reserved.]
dc.languageeng
dc.sourceeissn: 1873-3344
dc.subjectAnticancer potential
dc.subjectDNA interaction
dc.subjectDrug encapsulation
dc.subjectMagnetic cationic liposomes
dc.subjectTargeted drug delivery
dc.subjectVanadium-curcumin complexes
dc.titleMagnetic cationic liposomal nanocarriers for the efficient drug delivery of a curcumin-based vanadium complex with anticancer potential.
dc.typearticle
dc.date.updated2019-09-06T01:07:00Z
dc.date.accepted2019-07-14


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