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dc.contributor.authorNye, Gareth
dc.contributor.authorerlich, alexander
dc.contributor.authorBrownbill, Paul
dc.contributor.authorChernyavsky, Igor
dc.contributor.authorJenson, Oliver
dc.date.accessioned2019-08-19T08:25:06Z
dc.date.available2019-08-19T08:25:06Z
dc.date.issued2019-08-16
dc.identifier.citationErlich, A., Nye, G. A., Brownbill, P., Jensen, O. E. & Chernyavsky, I. L. (2019). Quantifying the impact of tissue metabolism on solute transport in feto-placental microvascular networks. Interface Focus, 9(5).en_US
dc.identifier.issn2042-8898
dc.identifier.doi10.1098/rsfs.2019.0021
dc.identifier.urihttp://hdl.handle.net/10034/622512
dc.description.abstractThe primary exchange units in the human placenta are terminal villi, in which fetal capillary networks are surrounded by a thin layer of villous tissue, separating fetal from maternal blood. To understand how the complex spatial structure of villi influences their function, we use an image-based theoretical model to study the effect of tissue metabolism on the transport of solutes from maternal blood into the fetal circulation. For solute that is taken up under first-order kinetics, we show that the transition between flow-limited and diffusion-limited transport depends on two new dimensionless parameters defined in terms of key geometric quantities, with strong solute uptake promoting flow-limited transport conditions. We present a simple algebraic approximation for solute uptake rate as a function of flow conditions, metabolic rate and villous geometry. For oxygen, accounting for nonlinear kinetics using physiological parameter values, our model predicts that villous metabolism does not significantly impact oxygen transfer to fetal blood, although the partitioning of fluxes between the villous tissue and the capillary network depends strongly on the flow regimeen_US
dc.language.isoenen_US
dc.publisherRoyal Societyen_US
dc.relation.urlhttps://royalsocietypublishing.org/doi/10.1098/rsfs.2019.0021en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.titleQuantifying the impact of tissue metabolism on solute transport in feto-placental microvascular networksen_US
dc.typeArticleen_US
dc.identifier.eissn2042-8901
dc.contributor.departmentUniversity of Manchesteren_US
dc.identifier.journalInterface Focusen_US
dc.date.accepted2019-05-20
or.grant.openaccessYesen_US
rioxxterms.funderunfundeden_US
rioxxterms.identifier.projectunfundeden_US
rioxxterms.versionVoRen_US
rioxxterms.licenseref.startdate2019-08-16
refterms.dateFCD2019-08-16T12:38:23Z
refterms.versionFCDAM
refterms.dateFOA2019-08-19T08:25:06Z


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