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dc.contributor.authorChiku, Charles
dc.contributor.authorZolfo, Maria
dc.contributor.authorSenkoro, Mbazi
dc.contributor.authorMabhala, Mzwandile A.
dc.contributor.authorTweya, Hannock
dc.contributor.authorMusasa, Patience
dc.contributor.authorShukusho, Fungai D.
dc.contributor.authorMazarura, Exervia
dc.contributor.authorMushavi, Angela
dc.contributor.authorMangwanya, Douglas
dc.date.accessioned2019-08-08T19:08:42Z
dc.date.available2019-08-08T19:08:42Z
dc.date.issued2019-08-08
dc.date.submitted2018-12-14
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/622481/pone.0210136.pdf?sequence=3
dc.identifier.citationPLOS ONE, volume 14, issue 8, page e0210136
dc.identifier.urihttp://hdl.handle.net/10034/622481
dc.descriptionFrom PLOS via Jisc Publications Router
dc.descriptionHistory: received 2018-12-14, collection 2019, accepted 2019-07-21, epub 2019-08-08
dc.descriptionPublication status: Published
dc.description.abstractEarly infant diagnosis (EID) of HIV provides an opportunity for early HIV detection and access to appropriate Antiretroviral treatment (ART). Dried Blood Spot (DBS) samples are used for EID of exposed infants, born to HIV-positive mothers. However, DBS rejection rates in Zimbabwe have been exceeding the target of less than 2% per month set by the National Microbiology Reference Laboratory (NMRL), in Harare. The aim of this study was to determine the DBS sample rejection rate, the reasons for rejection and the possible associations between rejection and level of health facility where the samples were collected. This is an analytical cross-sectional study using routine DBS sample data from the NMRL in Harare, Zimbabwe, between January and December 2017.A total of 34 950 DBS samples were received at the NMRL. Of these, 1291(4%) were rejected. Reasons for rejection were insufficient specimen volume (72%), missing request form (11%), missing sample (6%), cross-contamination (6%), mismatch of information (4%) and clotted sample (1%). Samples collected from clinics/rural health facilities were five times more likely to be rejected compared to those from a central hospital. Rejection rates were above the set target of <2%. The reasons for rejection were ‘pre-analytical’ errors including labelling errors, missing or inconsistent data, and insufficient blood collected. Samples collected at primary healthcare facilities had higher rejection rates.
dc.languageen
dc.publisherPublic Library of Science
dc.rightsLicence for this article: http://creativecommons.org/licenses/by/4.0/
dc.sourceeissn: 1932-6203
dc.subjectResearch Article
dc.subjectPeople and places
dc.subjectBiology and life sciences
dc.subjectMedicine and health sciences
dc.subjectResearch and analysis methods
dc.titleCommon causes of EID sample rejection in Zimbabwe and how to mitigate them
dc.typeArticle
dc.date.updated2019-08-08T19:08:42Z
dc.date.accepted2019-07-21


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