Mechanisms of skeletal muscle ageing: avenues for therapeutic intervention
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Abstract
Age-related loss of muscle mass and function, termed sarcopenia, is a catastrophic process, which impacts severely on quality of life of older people. The mechanisms underlying sarcopenia are unclear and the development of optimal therapeutic interventions remains elusive. Impaired regenerative capacity, attenuated ability to respond to stress, elevated reactive oxygen species production and low-grade systemic inflammation are all key contributors to sarcopenia. Pharmacological intervention using compounds such as 17AAG, SS-31 and Bimagrumab or naturally occurring polyphenols to target specific pathways show potential benefit to combat sarcopenia although further research is required, particularly to identify the mechanisms by which muscle fibres are completely lost with increasing age.Citation
Lightfoot, A. P., McCormick, R., Nye, G. A., & McArdle, A. (2014). Mechanisms of skeletal muscle ageing; avenues for therapeutic intervention. Current Opinion in Pharmacology, 16, 116-121.Publisher
ElsevierJournal
Current Opinion in PharmacologyType
ArticleLanguage
enISSN
1471-4892EISSN
1471-4973ae974a485f413a2113503eed53cd6c53
10.1016/j.coph.2014.05.005
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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-nd/4.0/