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dc.contributor.authorNye, Gareth*
dc.contributor.authorSakellariou, Giorgos*
dc.contributor.authorPearson, Timothy*
dc.contributor.authorLightfoot, Adam*
dc.contributor.authorWells, Nicola*
dc.contributor.authorGiakoumaki, Ifigeneia*
dc.contributor.authorVasilaki, Aphrodite*
dc.contributor.authorGriffiths, Richard*
dc.contributor.authorJackson, Malcolm*
dc.contributor.authorMcArdle, Anne*
dc.date.accessioned2019-05-08T14:35:06Z
dc.date.available2019-05-08T14:35:06Z
dc.date.issued2016-09-29
dc.identifier.citationSakellariou, G., Pearson, T., Lightfoot, A., Nye, G., Wells, N., Giakoumaki, I., . . . McArdle, A. (2016). Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophy. Scientific Reports, 6(1), 33944
dc.identifier.doi10.1038/srep33944
dc.identifier.urihttp://hdl.handle.net/10034/622213
dc.description.abstractAge-related loss of skeletal muscle mass and function is a major contributor to morbidity and has a profound effect on the quality of life of older people. The potential role of age-dependent mitochondrial dysfunction and cumulative oxidative stress as the underlying cause of muscle aging remains a controversial topic. Here we show that the pharmacological attenuation of age-related mitochondrial redox changes in muscle with SS31 is associated with some improvements in oxidative damage and mitophagy in muscles of old mice. However, this treatment failed to rescue the age-related muscle fiber atrophy associated with muscle atrophy and weakness. Collectively, these data imply that the muscle mitochondrial redox environment is not a key regulator of muscle fiber atrophy during sarcopenia but may play a key role in the decline of mitochondrial organelle integrity that occurs with muscle aging.
dc.language.isoenen
dc.publisherNature Researchen_US
dc.relation.urlhttps://www.nature.com/articles/srep33944en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.subjectAntioxidant reactive oxygen species muscle ageingen_US
dc.titleMitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophyen_US
dc.typeArticleen_US
dc.identifier.eissn2045-2322
dc.contributor.departmentUniversity of Liverpool
dc.identifier.journalScientific Reportsen_US
dc.date.accepted2016-03-07
or.grant.openaccessYesen_US
rioxxterms.funderMRC NIHen_US
rioxxterms.identifier.projectG1002120en_US
rioxxterms.identifier.projectAG20591en_US
rioxxterms.versionVoRen_US
rioxxterms.versionofrecordhttp://doi.org/10.1038/srep33944
rioxxterms.licenseref.startdate2016-09-29


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