CIP2A- and SETBP1-mediated PP2A inhibition reveals AKT S473 phosphorylation to be a new biomarker in AML

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Authors
Hills, Robert
Burnett, Alan
Lucas, Claire
Scott, Laura
Carmell, Natasha
Holcroft, Alison
Clark, Richard
Affiliation
University of Liverpool, Royal Liverpool University hospital, University of Cardiff
Publication Date
2018-04-27

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Abstract
Key Points PP2A inhibition occurs in AML by 2 different pathways: CIP2A in normal karyotype patients and SETBP1 in adverse karyotype patients. AKTS473 phosphorylation is a predictor of survival, and diagnostic levels of AKTS473 could be a novel biomarker in AML.
Citation
Lucas, C. M., Scott, L. J., Carmell, N., Holcroft, A. K., Hills, R. K., Burnett, A. K. & Clark, R. E. (2018). CIP2A- and SETBP1-mediated PP2A inhibition reveals AKT S473 phosphorylation to be a new biomarker in AML. Blood advances, 2(9), 964-8.
Publisher
American Society for Hematology
Journal
Blood Advances
URI
http://hdl.handle.net/10034/622167
DOI
10.1182/bloodadvances.2017013615
Additional Links
http://www.bloodadvances.org/content/2/9/964/tab-article-info
Type
Article
Language
en
EISSN
2473-9529
2473-9537
Collections
http://creativecommons.org/licenses/by-nc-nd/4.0/
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-nd/4.0/