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dc.contributor.authorNnate, Daniel*
dc.contributor.authorMassey, Alan*
dc.contributor.authorRidgway, Victoria*
dc.contributor.authorMabhala, Mzwandile A.*
dc.date.accessioned2019-04-11T08:26:08Z
dc.date.available2019-04-11T08:26:08Z
dc.date.issued2018-11-28
dc.identifier.citationNnate, D. A., Massey, A., Ridgway, V. & Mabhala, M. A. (2018). Effectiveness of nitric oxide agents in preventing the early onset of pre-eclampsia and possible modification of metabolic factors in high-risk pregnancies. PROSPERO.
dc.identifier.otherna
dc.identifier.urihttp://hdl.handle.net/10034/622111
dc.description.abstractPre-eclampsia is a pregnancy-specific condition which affects at least 2 - 8% of pregnancies and is the major cause of foetal growth restriction, small gestational age and increased rate of preterm birth from induced labour and caesarean section. The rate of early-onset of pre-eclampsia raises serious concern; and the most affected population are nulliparous women, women with chronic hypertension, multiple pregnancies and those with chronic diseases. Increasing the bioavailability of nitric oxide (NO) in the endothelial system through the timely administration of NO agents could minimise the metabolic precursors of pre-eclampsia which may be a cost-effective intervention in preventing the complications related to the ailment. While the effectiveness and safety of suggested interventions for the prevention of pre-eclampsia on maternal and neonatal health is being deliberated, evidence on the role of NO in the pathogenesis of preeclampsia is well recognised. Nitric oxide agents have been proven to be effective in preventing complications from pre-eclampsia; however, there is limited evidence on NO agents in preventing its early onset in high risk pregnancies. Previous studies on pre-eclampsia prevention with NO agents lacks the criteria required to achieve optimum effects; and the benefit of administering NO agents before 20 weeks’ gestation is yet to be established.en_US
dc.language.isoenen_US
dc.publisherInternational prospective register of systematic reviewsen_US
dc.relation.ispartofseriesCRD42018099298en_US
dc.relation.urlhttp://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42018099298en_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.subjectNitric Oxideen_US
dc.subjectPre-Eclampsiaen_US
dc.subjectPregnancyen_US
dc.subjectHigh-Risken_US
dc.subjectMetabolic precursorsen_US
dc.titleEffectiveness of nitric oxide agents in preventing the early onset of pre-eclampsia and possible modification of metabolic factors in high-risk pregnanciesen_US
dc.title.alternativeNitric oxide agents in the prevention of pre-eclampsiaen_US
dc.typeArticleen_US
dc.contributor.departmentUniversity of Chester
dc.identifier.journalPROSPERO
dc.date.accepted2018-11-28
or.grant.openaccessYesen_US
rioxxterms.funderUnfundeden_US
rioxxterms.identifier.projectUnfundeden_US
rioxxterms.versionAMen_US
rioxxterms.licenseref.startdate2218-11-28


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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International