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dc.contributor.authorMc Auley, Mark T.*
dc.date.accessioned2019-04-08T08:24:52Z
dc.date.available2019-04-08T08:24:52Z
dc.date.issued2018-12-31
dc.identifier.citationMc Auley, M. (2018). The Interplay Between Cholesterol Metabolism and Intrinsic Ageing. In Harris J., Korolchuk V. (Eds.) Biochemistry and Cell Biology of Ageing: Part I Biomedical Science. Singapore, Springer.en
dc.identifier.isbn9789811328343
dc.identifier.urihttp://hdl.handle.net/10034/622093
dc.description.abstractThe last few decades have witnessed remarkable progress in our understanding of ageing. From an evolutionary standpoint it is generally accepted that ageing is a non-adaptive process which is underscored by a decrease in the force of natural selection with time. From a mechanistic perspective ageing is characterized by a wide variety of cellular mechanisms, including processes such as cellular senescence, telomere attrition, oxidative damage, molecular chaperone activity, and the regulation of biochemical pathways by sirtuins. These biological findings have been accompanied by an unrelenting rise in both life expectancy and the number of older people globally. However, despite age being recognized demographically as a risk factor for healthspan, the processes associated with ageing are routinely overlooked in disease mechanisms. Thus, a central goal of biogerontology is to understand how diseases such as cardiovascular disease (CVD) are shaped by ageing. This challenge cannot be ignored because CVD is the main cause of morbidity in older people. A worthwhile way to examine how ageing intersects with CVD is to consider the effects ageing has on cholesterol metabolism, because dysregualted cholesterol metabolism is the key factor which underpins the pathology of CVD. The aim of this chapter is to outline a hypothesis which accounts for how ageing intersects with intracellular cholesterol metabolism. Moreover, we discuss the implications of this relationship for the onset of disease in the 'oldest old' (individuals ≥85 years of age). We conclude the chapter by discussing the important role mathematical modelling has to play in improving our understanding of cholesterol metabolism and ageing.
dc.language.isoenen
dc.publisherSpringerLinken
dc.relation.urlhttps://link.springer.com/chapter/10.1007/978-981-13-2835-0_4en
dc.rightsCC0 1.0 Universal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectCardiovascular diseaseen
dc.subjectCholesterol metabolismen
dc.subjectReactive oxygen species; Oldest olden
dc.titleThe Interplay Between Cholesterol Metabolism and Intrinsic Ageingen
dc.typeBook chapteren
dc.contributor.departmentUniversity of Chesteren
or.grant.openaccessYesen
rioxxterms.funderunfundeden_US
rioxxterms.identifier.projectunfundeden_US
rioxxterms.versionAMen
rioxxterms.licenseref.startdate2218-12-31
rioxxterms.publicationdate2018-12-31
dc.dateAccepted2018-12-31
dc.date.deposited2019-04-08


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