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dc.contributor.authorMushtaq, Sohail*
dc.contributor.authorAhmed Fuzi, Salma F*
dc.date.accessioned2019-04-02T10:46:30Z
dc.date.available2019-04-02T10:46:30Z
dc.date.issued2019-03-01
dc.identifier.citationAhmad Fuzi, S., & Mushtaq, S. (2019). Vitamin D3 supplementation for 8 weeks leads to improved haematological status following the consumption of an iron-fortified breakfast cereal: A double-blind randomised controlled trial in iron-deficient women. British Journal of Nutrition, 12(10), 1146-57.
dc.identifier.issn0007-1145
dc.identifier.doi10.1017/S0007114519000412
dc.identifier.urihttp://hdl.handle.net/10034/622082
dc.descriptionThis article has been published in a revised form in British Journal of Nutrition http://doi.org/10.1017/S0007114519000412. This version is published under a Creative Commons CC-BY-NC-ND. No commercial re-distribution or re-use allowed. Derivative works cannot be distributed. © copyright holder.
dc.description.abstractThe effect of 38 µg (1500 IU) daily vitamin D3 supplementation, consumed with an iron-fortified breakfast cereal for 8 weeks, on haematological indicators in iron-deficient female subjects was investigated. Fifty iron-deficient subjects (plasma ferritin concentration < 20 µg/L; mean age ± SD: 27.4 ± 9.4 years) were randomised to consume an iron-fortified breakfast cereal containing 9 mg of iron daily, with either a vitamin D3 supplement or placebo. Blood samples were collected at baseline, interim (4 weeks) and post-intervention (8 weeks) for measurement of iron and vitamin D status biomarkers. The effect of intervention was analysed using mixed-model repeated measures ANOVA. Significant increases were observed in two main haematological indices: haemoglobin concentration and haematocrit level from baseline to post-intervention in the vitamin D group, but not in the placebo group. The increase from baseline to post-intervention in haemoglobin concentration in the vitamin D group (135 ± 11 to 138 ± 10 g/L) was significantly higher compared to the placebo group (131 ± 15 to 128 ± 13 g/L) (P=0.037). The increase in haematocrit level from baseline to post-intervention was also significantly higher in the vitamin D group (42.0 ± 3.0 to 43.8 ± 3.4%) compared to the placebo group (41.2 ± 4.3 to 40.7 ± 3.6%) (P=0.032). Despite the non-significant changes in plasma ferritin concentration, this study demonstrates that 38 µg supplemental vitamin D, consumed daily, with iron-fortified breakfast cereal led to improvement in haemoglobin concentration and haematocrit levels in women with low iron stores. These findings may have therapeutic implications in the recovery of iron status in iron-deficient populations at a healthcare level.
dc.language.isoenen
dc.publisherCambridge University Pressen_US
dc.relation.urlhttps://www.cambridge.org/core/journals/british-journal-of-nutrition/article/vitamin-d3-supplementation-for-8-weeks-leads-to-improved-haematological-status-following-the-consumption-of-an-ironfortified-breakfast-cereal-a-doubleblind-randomised-controlled-trial-in-irondeficient-women-12/BF1FD0291A110FF2D488064EF4A2BF40en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.subjectvitamin D supplementationen_US
dc.subjectiron statusen_US
dc.subjecthepcidinen_US
dc.subjectiron-fortified cerealsen_US
dc.titleVitamin D3 supplementation for 8 weeks leads to improved haematological status following the consumption of an iron-fortified breakfast cereal: a double-blind randomised controlled trial in iron-deficient women.en_US
dc.typeArticleen_US
dc.identifier.eissn1475-2662
dc.contributor.departmentUniversity of Chester
dc.identifier.journalBritish Journal of Nutritionen_US
dc.date.accepted2019-02-15
or.grant.openaccessYesen_US
rioxxterms.funderUnfundeden_US
rioxxterms.identifier.projectUnfundeden_US
rioxxterms.versionAMen_US
rioxxterms.licenseref.startdate2019-03-01
refterms.dateFCD2019-03-26T16:38:29Z
refterms.versionFCDAM
refterms.dateFOA2019-04-02T10:48:35Z


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