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dc.contributor.authorBaccarin, Marina*
dc.contributor.authorRowley-Neale, Samuel J.*
dc.contributor.authorCavalheiro, Éder T. G.*
dc.contributor.authorSmith, Graham C.*
dc.contributor.authorBanks, Craig E.*
dc.date.accessioned2019-03-27T01:28:56Z
dc.date.available2019-03-27T01:28:56Z
dc.date.issued2019-02-22
dc.identifierpmid: 30796537
dc.identifierdoi: 10.1007/s00604-019-3315-y
dc.identifierpmcid: PMC6394810
dc.identifier.citationMikrochimica acta, volume 186, issue 3, page 200en
dc.identifier.urihttp://hdl.handle.net/10034/622051
dc.descriptionFrom Europe PMC via Jisc Publications Router
dc.descriptionHistory: ppub 2019-02-01, epub 2019-02-22
dc.descriptionPublication status: Published
dc.description.abstractThe electroanalytical detection of the neurotransmitter dopamine (DA) in the presence of uric acid (UA) is explored for the first time using commercially procured nanodiamonds (NDs). These are electrically wired via surface modification upon screen-printed graphite macroelectrodes (SPEs). The surface coverage of the NDs on the SPEs was explored in order to optimize electroanalytical outputs to result in well-resolved signals and in low limits of detection. The (electro)analytical outputs are observed to be more sensitive than those achieved at bare (unmodified) SPEs. Such responses, previously reported in the academic literature have been reported to be electrocatalytic and have been previously attributed to the presence of surface sp2 carbon and oxygenated species on the surface of the NDs. However, XPS analysis reveals the commercial NDs to be solely composed of nonconductive sp3 carbon. The low/negligible electroconductivity of the NDs was further confirmed when ND paste electrodes were fabricated and found to exhibit no electrochemical activity. The electroanalytical enhancement, when using NDs electronically wired upon SPEs, is attributed not to the NDs themselves being electrocatalytic, as reported previously, but rather changes in mass transport where the inert NDs block the underlying electroactive SPEs and create a random array of graphite microelectrodes. The electrode was applied to simultaneous sensing of DA and UA at pH 5.5. Figures of merit include (a) low working potentials of around 0.27 and 0.35 V (vs. Ag/AgCl); and (b) detection limits of 5.7 × 10-7 and 8.9 × 10-7 M for DA and UA, respectively. Graphical abstract The electroanalytical enhancement of screen-printed electrodes modified with inert/non-conductive nanodiamonds is due to a change in mass transfer where the inert nanodiamonds facilitate the production of a random microelectrode array.
dc.languageeng
dc.rightsLicence for this article: cc by
dc.sourceessn: 1436-5073
dc.sourcenlmid: 7808782
dc.sourceissn: 0026-3672
dc.subjectDopamineen
dc.subjectDetectionen
dc.subjectElectrochemistryen
dc.subjectUric aciden
dc.subjectElectrocatalysisen
dc.subjectNanodiamondsen
dc.subjectMicro-electrode Arrayen
dc.subjectScreen-printed Electrodesen
dc.titleNanodiamond based surface modified screen-printed electrodes for the simultaneous voltammetric determination of dopamine and uric acid.en
dc.typearticleen
dc.date.updated2019-03-27T01:28:56Z


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