Show simple item record

dc.contributor.authorPapadopoulos, Theodoros A.*
dc.contributor.authorSmith, Graham C.*
dc.contributor.authorHalevas, Eleftherios*
dc.contributor.authorSalifoglou, Athanasios*
dc.contributor.authorSwanson, Claudia H.*
dc.contributor.authorHatzidimitriou, Antonios*
dc.contributor.authorKatsipis, George
dc.contributor.authorPantazaki, Anastasia
dc.contributor.authorSanakis, I.
dc.contributor.authorMitrikas, George
dc.contributor.authorYpsilantis, Konstantinos
dc.contributor.authorLitsardakis, George
dc.date.accessioned2018-11-29T15:47:33Z
dc.date.available2018-11-29T15:47:33Z
dc.date.issued2018-11-06
dc.identifier.citationHalevas, E., Papadopoulos, T. A., Swanson, C. H., Smith, G. C., Hatzidimitriou, A., Katsipis, G., . . . Salifoglou, A. (2018). In-depth synthetic, physicochemical and in vitro biological investigation of a new ternary V(IV) antioxidant material based on curcumin. Journal of Inorganic Biochemistry, 191, 94-111.en
dc.identifier.issn0162-0134
dc.identifier.doi10.1016/j.jinorgbio.2018.10.010
dc.identifier.urihttp://hdl.handle.net/10034/621599
dc.description.abstractCurcumin is a natural product with a broad spectrum of beneficial properties relating to pharmaceutical applications, extending from traditional remedies to modern cosmetics. The biological activity of such pigments, however, is limited by their solubility and bioavailability, thereby necessitating new ways of achieving optimal tissue cellular response and efficacy as drugs. Metal ion complexation provides a significant route toward improvement of curcumin stability and biological activity, with vanadium being a representative such metal ion, amply encountered in biological systems and exhibiting exogenous bioactivity through potential pharmaceuticals. Driven by the need to optimally increase curcumin bioavailability and bioactivity through complexation, synthetic efforts were launched to seek out stable species, ultimately leading to the synthesis and isolation of a new ternary V(IV)-curcumin-(2,2’-bipyridine) complex. Physicochemical characterization (elemental analysis, FT-IR, Thermogravimetry (TGA), UV-Visible, NMR, ESI-MS, Fluorescence, X-rays) portrayed the solid-state and solution properties of the ternary complex. Pulsed-EPR spectroscopy, in frozen solutions, suggested the presence of two species, cis- and trans-conformers. Density Functional Theory (DFT) calculations revealed the salient features and energetics of the two conformers, thereby complementing EPR spectroscopy. The well-described profile of the vanadium species led to its in vitro biological investigation involving toxicity, cell metabolism inhibition in S. cerevisiae cultures, Reactive Oxygen Species (ROS)-suppressing capacity, lipid peroxidation, and plasmid DNA degradation. A multitude of bio-assays and methodologies, in comparison to free curcumin, showed that it exhibits its antioxidant potential in a concentration-dependent fashion, thereby formulating a bioreactivity profile supporting development of new efficient vanado-pharmaceuticals, targeting (extra)intra-cellular processes under (patho)physiological conditions.
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttps://www.sciencedirect.com/science/article/pii/S0162013418303696en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectVanadium-curcumin complexen
dc.subjectcrystal structure and DFT calculationsen
dc.subjectROS-suppressionen
dc.subjectcell metabolism inhibition and DNA degradationen
dc.subjectbioreactivity profile and antioxidant agenten
dc.subjecthybrid metallopharmaceuticalen
dc.titleIn-depth synthetic, physicochemical and in vitro biological investigation of a new ternary V(IV) antioxidant material based on curcumin.en
dc.typeArticleen
dc.identifier.eissn1873-3344
dc.contributor.departmentUniversity of Chester; Aristotle Universityen
dc.identifier.journalJournal of Inorganic Biochemistry
or.grant.openaccessYesen
rioxxterms.funderIKY Fellowships of Excellence for Postgraduate studies in Greece-Siemens Program 2016-2017en_US
rioxxterms.identifier.projectN/Aen_US
rioxxterms.versionAMen
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.jinorgbio.2018.10.010
rioxxterms.licenseref.startdate2019-11-06
rioxxterms.publicationdate2018-11-06
dc.dateAccepted2018-10-23
dc.date.deposited2018-11-29


Files in this item

Thumbnail
Name:
Publisher version
Thumbnail
Name:
Manuscript.pdf
Size:
1.870Mb
Format:
PDF
Request:
Main article

This item appears in the following Collection(s)

Show simple item record

http://creativecommons.org/licenses/by-nc-nd/4.0/
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-nd/4.0/