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    Human adipose tissue-derived mesenchymal stem/stromal cells adhere to and inhibit the growth of Staphylococcus aureus and Pseudomonas aeruginosa.

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    Authors
    Wood, Chelsea R.
    Al Dhahri, Douaa
    Pickles, Neil
    Sammons, Rachel L.
    Worthington, Tony
    Wright, Karina T.
    Johnson, William Eustace Basil
    Al-Delfi, Ibtesam R. T.
    Publication Date
    2018-10-23
    
    Metadata
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    Abstract
    We have cultured and phenotyped human adipose tissue-derived mesenchymal stem/stromal cells (AT MSCs) and inoculated these cultures with bacteria common to infected skin wounds, i.e. Staphylococcus aureus and Pseudomonas aeruginosa. Cell interactions were examined by scanning electron microscopy (SEM), whilst bacterial growth was measured by colony forming unit (c.f.u.) and biofilm assays. AT MSCs appeared to attach to the bacteria and to engulf S. aureus. Significantly fewer bacterial c.f.u. were present in AT MSC : bacterial co-cultures compared with bacteria cultured alone. Antibacterial activity, including an inhibition of P. aeruginosa biofilm formation, was observed when bacteria were treated with conditioned medium harvested from the AT MSC :  bacterial co-cultures, irrespective of the bacterial species to which the AT MSCs had been exposed to previously. Hence, we have demonstrated that AT MSCs inhibit the growth of two common bacterial species. This was associated with bacterial adhesion, potential engulfment or phagocytosis, and the secretion of antibacterial factors.
    Citation
    Journal of medical microbiology
    URI
    http://hdl.handle.net/10034/621523
    Type
    article
    Description
    From PubMed via Jisc Publications Router.
    Publication status: aheadofprint
    Collections
    Chester Medical School

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