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dc.contributor.authorHazell, Gavin*
dc.contributor.authorFisher, Leanne E.*
dc.contributor.authorMurray, Andrew W.*
dc.contributor.authorNobbs, Angela H.*
dc.contributor.authorSu, Bo*
dc.date.accessioned2018-06-11T15:12:06Z
dc.date.available2018-06-11T15:12:06Z
dc.date.issued2018-05-28
dc.identifier.citationHazell, G., et al (2018). Bioinspired bactericidal surfaces with polymer nanocone arrays. Journal of Colloid and Interface Science, 528, 389-399. https://doi.org/10.1016/j.jcis.2018.05.096en
dc.identifier.doi10.1016/j.jcis.2018.05.096
dc.identifier.urihttp://hdl.handle.net/10034/621179
dc.description.abstractInfections resulting from bacterial biofilm formation on the surface of medical devices are challenging to treat and can cause significant patient morbidity. Recently, it has become apparent that regulation of surface nanotopography can render surfaces bactericidal. In this study, poly(ethylene terephthalate) nanocone arrays are generated through a polystyrene nanosphere-mask colloidal lithographic process. It is shown that modification of the mask diameter leads to a direct modification of centre-to-centre spacing between nanocones. By altering the oxygen plasma etching time it is possible to modify the height, tip width and base diameter of the individual nanocone features. The bactericidal activity of the nanocone arrays was investigated against Escherichia coli and Klebsiella pneumoniae. It is shown that surfaces with the most densely populated nanocone arrays (center-to-center spacing of 200 nm), higher aspect ratios (>3) and tip widths <20 nm kill the highest percentage of bacteria (∼30%).
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttps://www.sciencedirect.com/science/article/pii/S0021979718306179en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectBiomaterialsen
dc.subjectBactericidalen
dc.subjectNanotopographyen
dc.subjectBioinspireden
dc.subjectNanoconeen
dc.titleBioinspired bactericidal surfaces with polymer nanocone arraysen
dc.typeArticleen
dc.identifier.eissn1095-7103
dc.contributor.departmentUniversity of Chester; University of Bristolen
dc.identifier.journalJournal of Colloid and Interface Science
or.grant.openaccessYesen
rioxxterms.funderMedical Research Councilen
rioxxterms.identifier.projectMR/N010345/1en
rioxxterms.versionAMen
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.jcis.2018.05.096
rioxxterms.licenseref.startdate2019-05-28
html.description.abstractInfections resulting from bacterial biofilm formation on the surface of medical devices are challenging to treat and can cause significant patient morbidity. Recently, it has become apparent that regulation of surface nanotopography can render surfaces bactericidal. In this study, poly(ethylene terephthalate) nanocone arrays are generated through a polystyrene nanosphere-mask colloidal lithographic process. It is shown that modification of the mask diameter leads to a direct modification of centre-to-centre spacing between nanocones. By altering the oxygen plasma etching time it is possible to modify the height, tip width and base diameter of the individual nanocone features. The bactericidal activity of the nanocone arrays was investigated against Escherichia coli and Klebsiella pneumoniae. It is shown that surfaces with the most densely populated nanocone arrays (center-to-center spacing of 200 nm), higher aspect ratios (>3) and tip widths <20 nm kill the highest percentage of bacteria (∼30%).
rioxxterms.publicationdate2018-05-28
dc.dateAccepted2018-05-27
dc.date.deposited2018-06-11


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