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University of Chester; University of BristolPublication Date
2018-05-28
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Infections resulting from bacterial biofilm formation on the surface of medical devices are challenging to treat and can cause significant patient morbidity. Recently, it has become apparent that regulation of surface nanotopography can render surfaces bactericidal. In this study, poly(ethylene terephthalate) nanocone arrays are generated through a polystyrene nanosphere-mask colloidal lithographic process. It is shown that modification of the mask diameter leads to a direct modification of centre-to-centre spacing between nanocones. By altering the oxygen plasma etching time it is possible to modify the height, tip width and base diameter of the individual nanocone features. The bactericidal activity of the nanocone arrays was investigated against Escherichia coli and Klebsiella pneumoniae. It is shown that surfaces with the most densely populated nanocone arrays (center-to-center spacing of 200 nm), higher aspect ratios (>3) and tip widths <20 nm kill the highest percentage of bacteria (∼30%).Citation
Hazell, G., et al (2018). Bioinspired bactericidal surfaces with polymer nanocone arrays. Journal of Colloid and Interface Science, 528, 389-399. https://doi.org/10.1016/j.jcis.2018.05.096Publisher
ElsevierAdditional Links
https://www.sciencedirect.com/science/article/pii/S0021979718306179Type
ArticleLanguage
enEISSN
1095-7103ae974a485f413a2113503eed53cd6c53
10.1016/j.jcis.2018.05.096
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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-nd/4.0/