Show simple item record

dc.contributor.authorSeddon, Jennifer L.*
dc.contributor.authorBirchwood, Max*
dc.contributor.authorCopello, Alex*
dc.contributor.authorEverard, Linda*
dc.contributor.authorJones, Peter B.*
dc.contributor.authorFowler, David*
dc.contributor.authorAmos, Tim*
dc.contributor.authorFreemantle, Nick*
dc.contributor.authorSharma, Vimal*
dc.contributor.authorMarshall, Max*
dc.contributor.authorSingh, Swaran P.*
dc.date.accessioned2018-06-07T11:50:27Z
dc.date.available2018-06-07T11:50:27Z
dc.date.issued2015-11-04
dc.identifier.citationSeddon, J. L., et al. (2016). Cannabis Use Is Associated With Increased Psychotic Symptoms and Poorer Psychosocial Functioning in First-Episode Psychosis: A Report From the UK National EDEN Study. Schizophrenia Bulletin, 42(3), 619-625. https://doi.org/10.1093/schbul/sbv154
dc.identifier.issn0586-7614
dc.identifier.doi10.1093/schbul/sbv154
dc.identifier.urihttp://hdl.handle.net/10034/621172
dc.descriptionThis is a pre-copyedited, author-produced PDF of an article accepted for publication in Schizophrenia Bulletin following peer review. The version of record Seddon, J. L., et al. (2016). Cannabis Use Is Associated With Increased Psychotic Symptoms and Poorer Psychosocial Functioning in First-Episode Psychosis: A Report From the UK National EDEN Study. Schizophrenia Bulletin, 42(3), 619-625. https://doi.org/10.1093/schbul/sbv154 is available online at: https://academic.oup.com/schizophreniabulletin/article/42/3/619/2413898#39400533
dc.description.abstractBackground: The use of cannabis during the early stage of psychosis has been linked with increased psychotic symptoms. This study aimed to examine the use of cannabis in the 12 months following a first-episode psychosis (FEP) and the link with symptomatic course and outcome over one year post psychosis onset. Method: 1027 FEP patients were recruited upon inception to specialised early intervention services for psychosis in the UK. Participants completed assessments at baseline, six and twelve months. Results: The results indicate that the use of cannabis was significantly associated with increased severity of psychotic symptoms, mania, depression and poorer psycho-social functioning. Continued use of cannabis following the first episode of psychosis was prognostic of outcome at one year. These associations were significant after adjusting for age, gender, DUP, age of psychosis onset, ethnicity and other drug use. Conclusion: This is the largest cohort study of first-episode psychosis patients receiving care within early intervention services. Cannabis use, in particular continued use, is associated with poorer symptomatic and functional outcome during the first-episode of psychosis. The results highlight the need for effective and early intervention for cannabis use in FEP.
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.urlhttps://academic.oup.com/schizophreniabulletin/article/42/3/619/2413898#39400533en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectCannabis useen
dc.subjectPsychotic symptomsen
dc.subjectFirst-episode psychosisen
dc.subjectProspective studyen
dc.titleCannabis use is associated with increased psychotic symptoms and poorer psycho-social functioning in first-episode psychosis: A report from the UK National EDEN studyen
dc.typeArticleen
dc.identifier.eissn1745-1701
dc.contributor.departmentUniversity of New South Wales; University of Warwick; University of Birmingham; Birmingham and Solihull Mental Health NHS Foundation Trust; Cambridge and Peterborough NHS Foundation Trust; University of Sussex; University of Bristol; UCL Medical School; University of Chester; University of Manchester;
dc.identifier.journalSchizophrenia Bulletin
dc.date.accepted2015-08-04
or.grant.openaccessYesen
rioxxterms.funderDepartment of Health and NIHRen
rioxxterms.identifier.projectRP-PG-0109-10074en
rioxxterms.versionAMen
rioxxterms.versionofrecordhttp://doi.org/10.1093/schbul/sbv154
rioxxterms.licenseref.startdate2015-11-04
html.description.abstractBackground: The use of cannabis during the early stage of psychosis has been linked with increased psychotic symptoms. This study aimed to examine the use of cannabis in the 12 months following a first-episode psychosis (FEP) and the link with symptomatic course and outcome over one year post psychosis onset. Method: 1027 FEP patients were recruited upon inception to specialised early intervention services for psychosis in the UK. Participants completed assessments at baseline, six and twelve months. Results: The results indicate that the use of cannabis was significantly associated with increased severity of psychotic symptoms, mania, depression and poorer psycho-social functioning. Continued use of cannabis following the first episode of psychosis was prognostic of outcome at one year. These associations were significant after adjusting for age, gender, DUP, age of psychosis onset, ethnicity and other drug use. Conclusion: This is the largest cohort study of first-episode psychosis patients receiving care within early intervention services. Cannabis use, in particular continued use, is associated with poorer symptomatic and functional outcome during the first-episode of psychosis. The results highlight the need for effective and early intervention for cannabis use in FEP.


Files in this item

Thumbnail
Name:
Cannabis use is associated with ...
Size:
78.58Kb
Format:
PDF
Request:
Main article

This item appears in the following Collection(s)

Show simple item record

http://creativecommons.org/licenses/by-nc-nd/4.0/
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-nd/4.0/