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dc.contributor.authorMc Auley, Mark T.*
dc.contributor.authorMorgan, Amy*
dc.contributor.authorMooney, Kathleen M.*
dc.date.accessioned2017-12-06T12:24:49Z
dc.date.available2017-12-06T12:24:49Z
dc.date.issued2017-10-25
dc.identifier.citationMc Auley, M., Morgan, A. & Mooney, K. (2017). The role of Mathematical Modelling in understanding Aging. In Ahmad, S. I. (ed.), Aging: Exploring a Complex Phenomenon. CRC Press.en
dc.identifier.issn9781138196971
dc.identifier.urihttp://hdl.handle.net/10034/620742
dc.description.abstractMathematical models have played key roles in developing our understanding of aging. The first pioneering mathematical models evaluated aging from an evolutionary perspective, generating meaningful insights into why aging occurs and laid the foundations for our current understanding of aging. More recently mathematical models have been used to gain a deeper understanding of the intracellular mechanisms associated with intrinsic aging. This chapter will outline what mathematical modelling is, and the advantages it has over more conventional approaches used in biogerontology. The steps involved in assembling a model will also be described and the leading theoretical frameworks underpinning them will be outlined. Moreover, we discuss in detail a variety of aging focused mechanistic mathematical models which have been developed in recent years. The chapter concludes by challenging the community to develop a unified mechanistic mathematical model which can be used to examine aging in a more integrated fashion.
dc.language.isoenen
dc.publisherCRC Pressen
dc.relation.urlhttps://www.crcpress.com/Aging-Exploring-a-Complex-Phenomenon/Ahmad/p/book/9781138196971en
dc.subjectagingen
dc.subjectMathematical modelingen
dc.titleThe role of Mathematical Modelling in understanding Agingen
dc.typeBook chapteren
dc.contributor.departmentUniversity of Chester, Edgehill Universityen
dc.date.accepted2017-03-01
or.grant.openaccessYesen
rioxxterms.funderunfundeden
rioxxterms.identifier.projectunfundeden
rioxxterms.versionAMen
rioxxterms.licenseref.startdate2217-10-25
refterms.dateFCD2019-08-05T14:37:30Z
refterms.versionFCDAM
html.description.abstractMathematical models have played key roles in developing our understanding of aging. The first pioneering mathematical models evaluated aging from an evolutionary perspective, generating meaningful insights into why aging occurs and laid the foundations for our current understanding of aging. More recently mathematical models have been used to gain a deeper understanding of the intracellular mechanisms associated with intrinsic aging. This chapter will outline what mathematical modelling is, and the advantages it has over more conventional approaches used in biogerontology. The steps involved in assembling a model will also be described and the leading theoretical frameworks underpinning them will be outlined. Moreover, we discuss in detail a variety of aging focused mechanistic mathematical models which have been developed in recent years. The chapter concludes by challenging the community to develop a unified mechanistic mathematical model which can be used to examine aging in a more integrated fashion.


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