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dc.contributor.authorGee, Brioney*
dc.contributor.authorHodgekins, Jo*
dc.contributor.authorFowler, David*
dc.contributor.authorMarshall, Max*
dc.contributor.authorEverard, Linda*
dc.contributor.authorLester, Helen*
dc.contributor.authorJones, Peter B.*
dc.contributor.authorAmos, Tim*
dc.contributor.authorSingh, Swaran P.*
dc.contributor.authorSharma, Vimal*
dc.contributor.authorFreemantle, Nick*
dc.contributor.authorBirchwood, Max*
dc.date.accessioned2017-04-11T12:37:55Z
dc.date.available2017-04-11T12:37:55Z
dc.date.issued2016-04-28
dc.identifier.citationGee, B., et. al. (2016). The course of negative symptom in first episode psychosis and the relationship with social recovery. Schizophrenia Research, 174(1-3), 165-71. DOI:10.1016/j.schres.2016.04.017
dc.identifier.doi10.1016/j.schres.2016.04.017
dc.identifier.urihttp://hdl.handle.net/10034/620475
dc.description.abstractAIMS: To investigate trajectories of negative symptoms during the first 12months of treatment for first episode psychosis (FEP), their predictors and relationship to social recovery. METHOD: 1006 participants were followed up for 12months following acceptance into Early Intervention in Psychosis services. Negative symptom trajectories were modelled using latent class growth analysis (LCGA) and predictors of trajectories examined using multinomial regression. Social recovery trajectories - also modelled using LCGA - of members of each negative symptom trajectory were ascertained and the relationship between negative symptom and social recovery trajectories examined. RESULTS: Four negative symptom trajectories were identified: Minimal Decreasing (63.9%), Mild Stable (13.5%), High Decreasing (17.1%) and High Stable (5.4%). Male gender and family history of non-affective psychosis predicted stably high negative symptoms. Poor premorbid adolescent adjustment, family history of non-affective psychosis and baseline depression predicted initially high but decreasing negative symptoms. Members of the Mild Stable, High Stable and High Decreasing classes were more likely to experience stably low functioning than the Minimal Decreasing class. CONCLUSIONS: Distinct negative symptom trajectories are evident in FEP. Only a small subgroup present with persistently high levels of negative symptoms. A substantial proportion of FEP patients with elevated negative symptoms at baseline will achieve remission of these symptoms within 12months. However, elevated negative symptoms at baseline, whether or not they remit, are associated with poor social recovery, suggesting targeted interventions for service users with elevated baseline negative symptoms may help improve functional outcomes.
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pubmed/27131912en
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S0920996416301669
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectThe National EDEN Studyen
dc.subjectEarly Psychosisen
dc.titleThe course of negative symptom in first episode psychosis and the relationship with social recoveryen
dc.typeArticleen
dc.identifier.eissn1573-2509
dc.contributor.departmentUniversity of East Anglia; University of Sussex; University of Manchester; Birmingham and Solihull Mental Health NHS Foundation Trust; University of Birmingham; University of Cambridge; University of Bristol; University of Warwick; University of Chester; University College London
dc.identifier.journalSchizophrenia Research
dc.internal.reviewer-noteEmailed re: version of work 11/04/17 SMen
dc.date.accepted2016-04-11
or.grant.openaccessYesen
rioxxterms.funderDepartment of Health UKen
rioxxterms.identifier.projectDoHen
rioxxterms.versionAMen
rioxxterms.versionofrecordhttp://doi.org/10.1016/j.schres.2016.04.017
rioxxterms.licenseref.startdate2017-04-28
html.description.abstractAIMS: To investigate trajectories of negative symptoms during the first 12months of treatment for first episode psychosis (FEP), their predictors and relationship to social recovery. METHOD: 1006 participants were followed up for 12months following acceptance into Early Intervention in Psychosis services. Negative symptom trajectories were modelled using latent class growth analysis (LCGA) and predictors of trajectories examined using multinomial regression. Social recovery trajectories - also modelled using LCGA - of members of each negative symptom trajectory were ascertained and the relationship between negative symptom and social recovery trajectories examined. RESULTS: Four negative symptom trajectories were identified: Minimal Decreasing (63.9%), Mild Stable (13.5%), High Decreasing (17.1%) and High Stable (5.4%). Male gender and family history of non-affective psychosis predicted stably high negative symptoms. Poor premorbid adolescent adjustment, family history of non-affective psychosis and baseline depression predicted initially high but decreasing negative symptoms. Members of the Mild Stable, High Stable and High Decreasing classes were more likely to experience stably low functioning than the Minimal Decreasing class. CONCLUSIONS: Distinct negative symptom trajectories are evident in FEP. Only a small subgroup present with persistently high levels of negative symptoms. A substantial proportion of FEP patients with elevated negative symptoms at baseline will achieve remission of these symptoms within 12months. However, elevated negative symptoms at baseline, whether or not they remit, are associated with poor social recovery, suggesting targeted interventions for service users with elevated baseline negative symptoms may help improve functional outcomes.


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