Authors
Mc Auley, Mark T.Martinez Guimera, Alvaro
Hodgson, David
McDonald, Neil
Mooney, Kathleen M.
Morgan, Amy
Proctor, Carole
Affiliation
University of Chester; Edgehill University; Newcastle UniversityPublication Date
2017-02-23
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The ageing process is driven at the cellular level by random molecular damage which slowly accumulates with age. Although cells possess mechanisms to repair or remove damage, they are not 100% efficient and their efficiency declines with age. There are many molecular mechanisms involved and exogenous factors such as stress also contribute to the ageing process. The complexity of the ageing process has stimulated the use of computational modelling in order to increase our understanding of the system, test hypotheses and make testable predictions. As many different mechanisms are involved, a wide range of models have been developed. This paper gives an overview of the types of models that have been developed, the range of tools used, modelling standards, and discusses many specific examples of models which have been grouped according to the main mechanisms that they address. We conclude by discussing the opportunities and challenges for future modelling in this field.Citation
Mc Auley, M. T., et. al.(2017). Modelling the molecular mechanisms of ageing. Bioscience reports, 37(1). DOI: 10.1042/BSR20160177Publisher
Portland PressJournal
Bioscience reportsAdditional Links
http://www.bioscirep.org/content/37/1/BSR20160177Type
ArticleLanguage
enDescription
This document is the Accepted Manuscript version of a published work that appeared in final form in Bioscience reports. To access the final edited and published work see http://www.bioscirep.org/content/37/1/BSR20160177.EISSN
1573-4935ae974a485f413a2113503eed53cd6c53
10.1042/BSR20160177
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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/